rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.720
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.720
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.720
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.720
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.720
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.720
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.720
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.720
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.720
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.720
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.720
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.720
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.720
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.720
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.
23614898
2013
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.720
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
0.720
GeneticVariation
BEFREE
Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C ).
24335517
2014
rs121913250
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
0.720
GeneticVariation
BEFREE
Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D)-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S )-mutation.
27863474
2016