NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Disease: Leukemia, Myelocytic, Acute ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.740 GeneticVariation BEFREE Our results show that molecular complementarity underlies the higher frequency and significantly worse prognosis associated with <i>NPM1</i>c/<i>FLT3-ITD</i> vs <i>NPM1/NRAS-G12D-</i>mutant AML and functionally confirm the role of <i>HOXA</i> genes in NPM1c-driven AML. 28835438 2017
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.740 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.740 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.740 GeneticVariation BEFREE To elucidate the downstream functions of activated NRAS in AML, we used a murine model that harbors Mll-AF9 and a tetracycline-repressible, activated NRAS (NRAS(G12V)). 25316678 2014
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.740 GeneticVariation BEFREE Treating recipient mice transplanted with primary Nras(G12D) AMLs with 2 potent allosteric mitogen-activated protein kinase kinase (MEK) inhibitors (PD0325901 or trametinib/GlaxoSmithKline 1120212) significantly prolonged survival and reduced proliferation but did not induce apoptosis, promote differentiation, or drive clonal evolution. 25361812 2014
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.740 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group. 22407852 2012
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. 22144181 2012
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		0.740 GeneticVariation BEFREE Injecting Mx1-Cre, LSL-Nras(G12D) mice with the MOL4070LTR retrovirus causes acute myeloid leukemia that faithfully recapitulates many aspects of human NRAS-associated leukemias, including cooperation with deregulated Evi1 expression. 21163920 2011
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.740 GeneticVariation CLINVAR Recurring mutations found by sequencing an acute myeloid leukemia genome. 19657110 2009
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. 19075190 2009
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR Recurring mutations found by sequencing an acute myeloid leukemia genome. 19657110 2009
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR Implications of NRAS mutations in AML: a study of 2502 patients. 16434492 2006
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study. 2278970 1990
dbSNP: rs121913237
rs121913237
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.740 GeneticVariation CLINVAR RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. 3122217 1987