NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Disease: melanoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.700 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo. 23431193 2013
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. 20179705 2010
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.700 CausalMutation CLINVAR RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. 20179705 2010
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. 20130576 2010
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. 20130576 2010
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. 20179705 2010
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.700 CausalMutation CLINVAR RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. 20130576 2010
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. 18390968 2008
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. 18390968 2008
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors. 18375819 2008
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.700 CausalMutation CLINVAR Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. 18390968 2008
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.700 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983 2005
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983 2005
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983 2005
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR Ras mutations in human melanoma: a marker of malignant progression. 8120410 1994
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.700 CausalMutation CLINVAR Ras mutations in human melanoma: a marker of malignant progression. 8120410 1994
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR Ras mutations in human melanoma: a marker of malignant progression. 8120410 1994
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.700 CausalMutation CLINVAR N-ras mutations in human cutaneous melanoma from sun-exposed body sites. 2674680 1989
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.700 CausalMutation CLINVAR N-ras mutations in human cutaneous melanoma from sun-exposed body sites. 2674680 1989
dbSNP: rs121434596
rs121434596
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.700 CausalMutation CLINVAR N-ras mutations in human cutaneous melanoma from sun-exposed body sites. 2674680 1989