rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.700
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.
23431193
2013
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.700
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.700
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors.
18375819
2008
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.700
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.700
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.700
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.700
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.700
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989
rs121434596
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.700
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989