rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
0.740
GeneticVariation
BEFREE
Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D )-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S)-mutation.
27863474
2016
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
0.740
GeneticVariation
BEFREE
In a limited validation of potentially actionable low frequency mutations, a NRAS G12D mutation in a melanoma was shown to be a false positive.
24885028
2014
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.740
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.740
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
0.740
GeneticVariation
BEFREE
To produce a m ouse model of NRAS-driven melanoma , we expressed oncogenic NRAS (NRAS(G12D )) in mouse melanocytes.
23303902
2013
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
0.740
GeneticVariation
BEFREE
At clinically informative sites, we identified seven low-frequency point mutations (0.2%-4.7%), including BRAF p.V600E (melanoma , 0.2% alternate allele frequency), KRAS p.G12V (lung, 0.6%), JAK2 p.V617F (melanoma , colon, two lung, 0.3%-1.4%), and NRAS p.Q61R (colon, 4.7%).
23382536
2013
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.740
CausalMutation
CLINVAR
MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study.
23414587
2013
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.740
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.740
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.740
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.740
CausalMutation
CLINVAR
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
20130576
2010
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.740
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.740
CausalMutation
CLINVAR
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
20179705
2010
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.740
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.740
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.740
CausalMutation
CLINVAR
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.
18390968
2008
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.740
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.740
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.740
CausalMutation
CLINVAR
Distinct sets of genetic alterations in melanoma.
16291983
2005
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.740
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.740
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.740
CausalMutation
CLINVAR
Ras mutations in human melanoma: a marker of malignant progression.
8120410
1994
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
G
0.740
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
T
0.740
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989
rs121913237
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
melanoma
A
0.740
CausalMutation
CLINVAR
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
2674680
1989