NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Disease: melanoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		0.720 GeneticVariation BEFREE Since hypoxic microenvironments select for tumor cells with diminished therapeutic response, we investigated whether hypoxia unequally increases resistance to 3-BrPA in wt p53 MelJuso melanoma harbouring (Q61L)-mutant NRAS and wt BRAF, C8161 melanoma with (G12D)-mutant KRAS (G464E)-mutant BRAF, and A549 lung carcinoma with a KRAS (G12S)-mutation. 27863474 2016
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		0.720 GeneticVariation BEFREE Direct sequencing of the melanoma revealed a rarely described NRAS mutation c.34G>T (G12C). 24335517 2014
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.720 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. 23614898 2013
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. 23414587 2013
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.720 CausalMutation CLINVAR RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. 20130576 2010
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.720 CausalMutation CLINVAR RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. 20179705 2010
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. 20179705 2010
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. 20130576 2010
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. 20130576 2010
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. 20179705 2010
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.720 CausalMutation CLINVAR Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. 18390968 2008
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. 18390968 2008
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. 18390968 2008
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983 2005
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.720 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983 2005
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR Distinct sets of genetic alterations in melanoma. 16291983 2005
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR Ras mutations in human melanoma: a marker of malignant progression. 8120410 1994
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.720 CausalMutation CLINVAR Ras mutations in human melanoma: a marker of malignant progression. 8120410 1994
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR Ras mutations in human melanoma: a marker of malignant progression. 8120410 1994
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		A 0.720 CausalMutation CLINVAR N-ras mutations in human cutaneous melanoma from sun-exposed body sites. 2674680 1989
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		G 0.720 CausalMutation CLINVAR N-ras mutations in human cutaneous melanoma from sun-exposed body sites. 2674680 1989
dbSNP: rs121913250
rs121913250
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease:
melanoma 		T 0.720 CausalMutation CLINVAR N-ras mutations in human cutaneous melanoma from sun-exposed body sites. 2674680 1989