rs1052133
|
OGG1;CAMK1
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
This meta-analysis showed the evidence that hOGG1 Ser326Cys polymorphism was associated with a decreased risk of prostate cancer development in mixed populations.
|
21914193 |
2011 |
rs1052133
|
OGG1;CAMK1
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
XPD Asp312Asn polymorphism is associated with PCa risk in Asians and hOGG1 Ser326Cys polymorphism is associated with PCa risk in Caucasians and Asians.
|
22890093 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
Although no positive relation was discovered in the pooled analysis, significant associations between rs1052133 and Pca were found in the Asian population (recessive: odds ratio [OR] = 1.580, 95% confidence interval [95% CI], 1.189-2.098; GG vs. GC: OR = 1.504, 95% CI, 1.114-2.030; GG vs. CC: OR = 1.677, 95% CI, 1.201-2.342; allele analysis: OR = 1.249, 95% CI, 1.077-1.449), whites (dominant: OR = 2.138, 95% CI, 1.483-3.083; recessive: OR = 3.143, 95% CI, 1.171-8.437; GG vs. CC: OR = 3.992, 95% CI, 1.891-8.431; allele analysis: OR = 1.947, 95% CI, 1.467-2.586) and mixed populations (recessive: OR = 0.636, 95% CI, 0.484-0.834; GG vs. GC: OR = 0.654, 95% CI, 0.492-0.871; GG vs. CC: OR = 0.624, 95% CI, 0.473-0.823; allele analysis: OR = 0.857, 95% CI, 0.771-0.954).
|
25907663 |
2015 |
rs1052133
|
OGG1;CAMK1
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
These results suggest that hOGG1 may have a role in the repair of 8-OH-dG adducts in prostate tissue and hOGG1 Ser326Cys polymorphism is associated with prostate cancer risk.
|
14634453 |
2003 |
rs1052133
|
OGG1;CAMK1
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
To investigate potential non-receptor-mediated estrogen effects, we evaluated the association between COMT Val158Met and hOGG1 Ser326Cys polymorphisms and prostate cancer in a family-based case-control study (439 prostate cancer cases, 479 brother controls).
|
16569655 |
2006 |
rs1052133
|
OGG1;CAMK1
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined the association between PC risk with nonsynonymous SNPs (nsSNPs) in 5 genes involved in 3 DNA-repair pathways: (1) base excision repair (BER): hOGG1 C1245G (Ser326Cys) and XRCC1 G28152A (Arg399Gln); (2) nucleotide excision repair (NER): XPD G23591A (Asp312Asn); (3) homologous recombination repair: RAD51 G135C (in 5' untranslated region) and XRCC3 C18067T (Thr241Met).
|
19914098 |
2012 |
rs1052133
|
OGG1;CAMK1
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation |
BEFREE |
After adjustment for confounders, subjects who were heterozygous or homozygous for the variant allele of the hOGG1 Ser326Cys polymorphism appeared to experience a lower risk of prostate cancer than those who were homozygous for the wild-type allele (odds ratio [OR] (95% confidence interval [CI]): 0.72 (0.46-1.10)].
|
19914697 |
2010 |