SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Disease: Meningitis, Pneumococcal ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799889
rs1799889
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0025295
Disease:
Meningitis, Pneumococcal 		0.010 GeneticVariation BEFREE The rs1799889 5G/5G genotype was associated with an increased risk of unfavourable outcome [odds ratio (OR) 1.69, 95 % confidence interval (CI) 1.03-2.78] and mortality (OR 2.20, 95 % CI 1.02-4.86) in white adults with pneumococcal meningitis. rs1799889 was associated with CSF PAI-1 concentrations (P = 0.048), and white patients homozygous for the low PAI-1 producing genotype (5G/5G) had a significantly higher risk for cerebral infarctions (P = 0.015) and haemorrhages (P = 0.005). 24248324 2014