SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Disease: Ischemic stroke ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799889
rs1799889
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0948008
Disease:
Ischemic stroke 		0.020 GeneticVariation BEFREE A total of nine gene variants/polymorphisms - F5 (Leiden - R5 06Q, rs6025), F2 (20210G > A, rs1799963), F13A1 (V34L, rs5985), MTHFR (677C > T - A222V, rs1801133), MTHFR (1298A > C - E429A, rs1801131), FGB (-455G > A -c.-463G > A; rs1800790), SERPINE1 (PAI14G/5G - rs1799889), ACE (ACE I/D, rs1799752), ITGB3 (GPIIIa L33P, rs5918) and the APOE E2/E3/E4 alleles (rs7412, rs429358) - were genotyped in 200 newly diagnosed ischemic stroke (IS) patients, 165 patients with ischemic coronary heart disease (CHD) and 159 controls with no cerebroor cardiovascular disease (non-CVD). 27629735 2016
dbSNP: rs1799889
rs1799889
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0948008
Disease:
Ischemic stroke 		0.020 GeneticVariation BEFREE Furthermore, COC users with rs1799889 4G5G/5G5G genotype had a decreased risk of ischemic stroke (OR=0.53, 95% CI=0.34-0.83). 25231632 2014