GAL, galanin and GMAP prepropeptide, 51083

N. diseases: 226; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057517661
rs1057517661
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C4225318
Disease:
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
0.700 GeneticVariation UNIPROT
dbSNP: rs948854
rs948854
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C0086132
Disease:
Depressive Symptoms
0.020 GeneticVariation BEFREE Furthermore, rs948854 minor (G) allele was associated with depressive symptoms. 28987550 2018
dbSNP: rs948854
rs948854
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C0086132
Disease:
Depressive Symptoms
0.020 GeneticVariation BEFREE In premenopausal female MDD patients, the same allele of rs948854 was associated with more severe vegetative but not cognitive depressive symptoms at discharge and worse treatment response on antidepressant medication. 20237460 2010
dbSNP: rs948854
rs948854
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE In conclusion, the SNP rs948854 in the GAL gene seems to be involved in the modulation of depressive state, especially in individuals with GG genotype. 28987550 2018
dbSNP: rs948854
rs948854
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C0026769
Disease:
Multiple Sclerosis
0.010 GeneticVariation BEFREE These data demonstrate for the first time an association between rs948854 polymorphism and multiple sclerosis and, further, that this association is sex specific. 27870457 2017
dbSNP: rs1057517661
rs1057517661
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C0014556
Disease:
Epilepsy, Temporal Lobe
0.010 GeneticVariation BEFREE These findings suggest that the p.A39E mutant could impair galanin signaling in the hippocampus, leading to increased glutamatergic excitation and ultimately to TLE. 25691535 2015
dbSNP: rs694066
rs694066
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE Compared with the healthy controls, lower frequency of G/G genotype and higher frequency of A/G genotype were observed in rs694066 in MDD patients, a lower frequency of G-allele and higher frequency of A-allele were observed in rs694066. 23741354 2013
dbSNP: rs948854
rs948854
Entrez Id: 51083;107984343
Gene Symbol: GAL;LOC107984343
GAL;LOC107984343
CUI: C0524662
Disease:
Opiate Addiction
0.010 GeneticVariation BEFREE The most significant associations with opioid addiction (remaining significant after adjustment for multiple testing) were observed for the rs948854 SNP in the galanin gene (GAL, p = 0.001) and the rs2236861 SNP in the delta opioid receptor gene (OPRD1, p = 0.001). 24086514 2013