|
rs1514175
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight loci, rs10968576 (BDNF), rs3817334 (MTCH2), rs1558902 (FTO), rs571312 (MC4R), rs543874 (SEC16B), rs987237 (TFAP2B), rs2867125 (TMEM18) and rs7138803 (FAIM2), were previously known obesity susceptibility loci, and the remaining four loci, rs1514175 (TNNI3K), rs206936 (NUDT3), rs4771122 (MTIF3) and rs2241423 (MAP2K5), were newly identified as BMI loci by the GIANT study.
|
22041983 |
2012 |
|
rs202238194
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Cardiomyopathies
|
|
0.010 |
GeneticVariation |
BEFREE |
Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys).
|
30010057 |
2019 |
|
rs274609
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Pediatric Obesity
|
|
0.010 |
GeneticVariation |
BEFREE |
Six obesity-associated SNPs significantly departed from additive to dominant (N = 5) or recessive (N = 1) models, and a significant interaction was found between rs274609 (TNNI3K) and rs1010553 (ITIH4) on childhood obesity risk.
|
29769702 |
2019 |
|
rs606231469
|
TNNI3K;FPGT-TNNI3K
|
CARDIAC CONDUCTION DISEASE WITH OR WITHOUT DILATED CARDIOMYOPATHY
|
A |
0.800 |
CausalMutation |
CLINVAR |
|
|
|
|
rs202238194
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
CARDIAC CONDUCTION DISEASE WITH OR WITHOUT DILATED CARDIOMYOPATHY
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs202238194
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
CARDIAC CONDUCTION DISEASE WITH OR WITHOUT DILATED CARDIOMYOPATHY
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1514174
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Obesity
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs1514177
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Obesity
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
rs1040070
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Age at menarche
|
|
0.700 |
GeneticVariation |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
rs12041852
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
|
26604143 |
2016 |
|
rs12042908
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
|
30108127 |
2018 |
|
rs12566985
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genetic studies of body mass index yield new insights for obesity biology.
|
25673413 |
2015 |
|
rs12566985
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Smoking
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
|
28443625 |
2017 |
|
rs12566985
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
|
28443625 |
2017 |
|
rs12566985
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.
|
28892062 |
2017 |
|
rs12566985
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
|
26604143 |
2016 |
|
rs1514174
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
C |
0.700 |
GeneticVariation |
GWASCAT |
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
|
26426971 |
2015 |
|
rs1514175
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
|
23669352 |
2013 |
|
rs1514175
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
20935630 |
2010 |
|
rs1514177
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
rs4650277
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Smoking
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
|
30643258 |
2019 |
|
rs61778068
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
mathematical ability
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
rs6604866
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Hip circumference
|
C |
0.700 |
GeneticVariation |
GWASCAT |
New genetic loci link adipose and insulin biology to body fat distribution.
|
25673412 |
2015 |
|
rs7514705
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Age at menarche
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
|
25231870 |
2014 |
|
rs7526762
|
TNNI3K;FPGT-TNNI3K;LRRC53
|
Body mass index
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
|
28448500 |
2017 |