ANGPTL4, angiopoietin like 4, 51129

N. diseases: 198; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.030 GeneticVariation BEFREE Conflicting results have been obtained regarding whether the E40K variant (a loss-of-function mutation of Angptl4) is associated with an increased risk for cardiovascular disease, which may occur due to the lipid-independent actions of Angptl4. 19851103 2010
dbSNP: rs7255436
rs7255436
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs7255436
rs7255436
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0392885
Disease:
High density lipoprotein measurement 		C 0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs7255436
rs7255436
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		C 0.700 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0392885
Disease:
High density lipoprotein measurement 		A 0.700 GeneticVariation GWASCAT Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. 28270201 2017
dbSNP: rs4076317
rs4076317
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0038454
Disease:
Cerebrovascular accident 		0.010 GeneticVariation BEFREE Fewer stroke cases were homozygous for variants of rs4076317 compared with the controls (7.0% vs. 10.9%). 26944173 2016
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0202236
Disease:
Triglycerides measurement 		A 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0392885
Disease:
High density lipoprotein measurement 		A 0.700 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C1956346
Disease:
Coronary Artery Disease 		A 0.710 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
dbSNP: rs1044250
rs1044250
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0023903
Disease:
Liver neoplasms 		0.010 GeneticVariation BEFREE In human embryonic kidney 293 and human hepatoma 7 cells compared with wild type, E40K and T266M showed significantly altered synthesis and secretion, respectively. 20829508 2010
dbSNP: rs1044250
rs1044250
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE In human embryonic kidney 293 and human hepatoma 7 cells compared with wild type, E40K and T266M showed significantly altered synthesis and secretion, respectively. 20829508 2010
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0427460
Disease:
Red cell distribution width determination 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0003850
Disease:
Arteriosclerosis 		0.030 GeneticVariation BEFREE Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study. 18809343 2008
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0004153
Disease:
Atherosclerosis 		0.030 GeneticVariation BEFREE Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study. 18809343 2008
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0202236
Disease:
Triglycerides measurement 		A 0.700 GeneticVariation GWASCAT Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels. 27036123 2016
dbSNP: rs2278236
rs2278236
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0392885
Disease:
High density lipoprotein measurement 		A 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
dbSNP: rs117760119
rs117760119
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.700 GeneticVariation GWASCAT Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. 30670697 2019
dbSNP: rs2278236
rs2278236
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.800 GeneticVariation GWASDB Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. 22629316 2012
dbSNP: rs2278236
rs2278236
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0428472
Disease:
Serum HDL cholesterol measurement 		0.700 GeneticVariation GWASDB Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project. 22629316 2012
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0392885
Disease:
High density lipoprotein measurement 		A 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0001948
Disease:
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0202236
Disease:
Triglycerides measurement 		A 0.700 GeneticVariation GWASCAT Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. 30698716 2019
dbSNP: rs1044250
rs1044250
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.010 GeneticVariation BEFREE So, T266M and E40K polymorphism predicts cardiovascular disease risk in Type 2 diabetic Tunisian population. 27004807 2016
dbSNP: rs116843064
rs116843064
Entrez Id: 51129
Gene Symbol: ANGPTL4
ANGPTL4
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.030 GeneticVariation BEFREE So, T266M and E40K polymorphism predicts cardiovascular disease risk in Type 2 diabetic Tunisian population. 27004807 2016