|
rs1003483
|
IGF2;IGF2-AS;INS-IGF2
|
Severe myopia
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in the INS-IGF2 region (rs2070762 and rs1003483), and the INSR gene (rs3745551 and rs2229429) showed significant association with HM (allelic P = 0.0085, 0.0494, 0.0171 and 0.0238, respectively).
|
25266237 |
2015 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus, Insulin-Dependent
|
C |
0.810 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus, Insulin-Dependent
|
C |
0.810 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.810 |
GeneticVariation |
BEFREE |
Characteristics included are age at multiple autoantibody positivity, sex, selected high-risk HLA-DR-DQ genotypes, relationship to a family member with T1D, autoantibody at seroconversion, <i>INS</i> gene (rs1004446_A), and non-HLA gene polymorphisms identified by the Type 1 Diabetes Genetics Consortium (T1DGC).
|
28903990 |
2017 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus, Insulin-Dependent
|
G |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Autoantibody measurement
|
G |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Multiple Sclerosis
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed an inverse association with IGFII rs3741211 and endometrial cancer risk (OR=0.79 (95% CI: 0.63, 0.99)) and IGFII rs1004446 and endometrial cancer risk (OR=0.80 (95% CI: 0.68, 0.94)).
|
21078522 |
2011 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms were associated with increased diabetes risk (rs10517086_A [<i>P</i> = 0.03], rs1534422_G [<i>P</i> = 0.006], and rs2327832_G [<i>P</i> = 0.03] in <i>TNFAIP3</i>) and one with decreased risk (rs1004446_A in <i>INS</i> [<i>P</i> = 0.006]).
|
28903990 |
2017 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Three single nucleotide polymorphisms were associated with increased diabetes risk (rs10517086_A [<i>P</i> = 0.03], rs1534422_G [<i>P</i> = 0.006], and rs2327832_G [<i>P</i> = 0.03] in <i>TNFAIP3</i>) and one with decreased risk (rs1004446_A in <i>INS</i> [<i>P</i> = 0.006]).
|
28903990 |
2017 |
|
rs1004446
|
IGF2;IGF2-AS;INS-IGF2
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed an inverse association with IGFII rs3741211 and endometrial cancer risk (OR=0.79 (95% CI: 0.63, 0.99)) and IGFII rs1004446 and endometrial cancer risk (OR=0.80 (95% CI: 0.68, 0.94)).
|
21078522 |
2011 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Hyperglycemia
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis of the associations including data from 1367 Hyperglycaemia and Adverse Pregnancy Outcome Study participants confirmed the paternally-transmitted fetal IGF2/INS SNP associations (rs10770125, P-value=3.2×10<sup>-8</sup>, rs2585, P-value=3.6×10<sup>-5</sup>) and the composite fetal imprinted gene allele score association (P-value=1.3×10<sup>-8</sup>), but not the maternally-transmitted fetal KCNQ1(OT1) associations (rs231841, P-value=0.4; rs7929804, P-value=0.2).
|
28392167 |
2017 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation |
BEFREE |
IGF2 rs10770125 was also associated with DN in male T1D patients of the GoKinD population (P=0.038, OR=0.67 95% CI 0.46-0.98).
|
22770937 |
2013 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
IGF2 rs10770125 was also associated with DN in male T1D patients of the GoKinD population (P=0.038, OR=0.67 95% CI 0.46-0.98).
|
22770937 |
2013 |
|
rs10770125
|
IGF2;IGF2-AS;INS-IGF2
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Four fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value=2×10<sup>-4</sup>) and INS rs2585 (P-value=7×10<sup>-4</sup>), and maternally-transmitted KCNQ1(OT1) rs231841 (P-value=1×10<sup>-3</sup>) and KCNQ1(OT1) rs7929804 (P-value=4×10<sup>-3</sup>), were used to construct a composite fetal imprinted gene allele score which was associated with maternal glucose concentrations (P-value=4.3×10<sup>-6</sup>, n=981, r<sup>2</sup>=2.0%) and GDM prevalence (odds ratio per allele 1.44 (1.15, 1.80), P-value=1×10<sup>-3</sup>, n=89 cases and 899 controls).
|
28392167 |
2017 |
|
rs149483638
|
IGF2;IGF2-AS;INS-IGF2
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
0.700 |
GeneticVariation |
GWASCAT |
A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
|
28838971 |
2017 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Crohn Disease
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Celiac Disease
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Ankylosing spondylitis
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Lupus Erythematosus, Systemic
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Autoimmune thyroiditis
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Juvenile arthritis
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
rs17885785
|
IGF2;IGF2-AS;INS-IGF2
|
Psoriasis
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |