|
rs4684677
|
GHRL;GHRLOS
|
Obesity
|
|
0.710 |
GeneticVariation |
BEFREE |
Replication of the nominal associations with obesity could not be confirmed in a German genome-wide association (GWA) study for rs4684677 and rs572169 polymorphisms.
|
19165163 |
2009 |
|
rs34911341
|
GHRL;GHRLOS
|
Obesity
|
|
0.710 |
GeneticVariation |
BEFREE |
Arg51Gln mutation was associated with lower plasma ghrelin levels but not with obesity.
|
12181387 |
2002 |
|
rs34911341
|
GHRL;GHRLOS
|
Obesity
|
T |
0.710 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs4684677
|
GHRL;GHRLOS
|
Obesity
|
A |
0.710 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs3732950
|
SEC13;GHRL;GHRLOS
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs34911341
|
GHRL;GHRLOS
|
METABOLIC SYNDROME, SUSCEPTIBILITY TO
|
T |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs696217
|
GHRL;GHRLOS
|
METABOLIC SYNDROME, SUSCEPTIBILITY TO
|
T |
0.700 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs696217
|
GHRL;GHRLOS
|
OBESITY, AGE AT ONSET OF
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation |
BEFREE |
MTLRP genetic polymorphism (214C>A) was associated with Type 2 diabetes in Caucasian population: a meta-analysis.
|
25095788 |
2014 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation |
BEFREE |
The GHRL Leu72Met polymorphism may help to maintain normal renal function and may protect against the development of DN by reducing albuminuria and improving renal function in Chinese patients with type 2 diabetes.
|
24132517 |
2014 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation |
BEFREE |
The Leu72Met polymorphism of the preproghrelin gene was not associated with T2DM in Chinese population.
|
22441120 |
2012 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation |
BEFREE |
Recent studies have shown that the preproghrelin Leu72Met polymorphism is associated with serum creatinine (Scr) concentration in type 2 diabetes; 72Met carriers exhibited lower Scr levels as compared with the 72Met non-carriers.
|
16793966 |
2006 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation |
BEFREE |
Our data indicate that the preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus.
|
16483881 |
2006 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation |
BEFREE |
The Leu72Met polymorphism of the preproghrelin gene was not related to cardiovascular disease in type 2 diabetes mellitus patients.
|
12974878 |
2003 |
|
rs696217
|
GHRL;GHRLOS
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
Average dietary energy in lunch, rs3782886, and rs696217 were associated with obesity, and rs3782886 was associated with other metabolic abnormalities.
|
27245511 |
2019 |
|
rs696217
|
GHRL;GHRLOS
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
Minor homozygotes for five preproghrelin gene polymorphisms, namely, -1500C>G (rs3755777), -1062G>C (rs26311), -994C>T (rs26312) (promoter region), Leu72Met (rs696217) (exon 2), and +3056T>C (rs2075356) (intron 2), had high values of total and visceral fat areas, waist circumference, and BMI, indicating significant correlation of the polymorphisms with obesity and fat metabolism.
|
23257630 |
2013 |
|
rs696217
|
GHRL;GHRLOS
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes.
|
22441120 |
2012 |
|
rs696217
|
GHRL;GHRLOS
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome.
|
17884032 |
2008 |
|
rs696217
|
GHRL;GHRLOS
|
Obesity
|
|
0.050 |
GeneticVariation |
BEFREE |
The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children.
|
16459454 |
2005 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation |
BEFREE |
The GHRL Leu72Met polymorphism may help to maintain normal renal function and may protect against the development of DN by reducing albuminuria and improving renal function in Chinese patients with type 2 diabetes.
|
24132517 |
2014 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes
|
|
0.020 |
GeneticVariation |
BEFREE |
The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes.
|
22441120 |
2012 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation |
BEFREE |
The Leu72Met (+408C>A) polymorphism of the preproghrelin, has been linked to obesity, insulin resistance and diabetes.
|
22441120 |
2012 |
|
rs696217
|
GHRL;GHRLOS
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation |
BEFREE |
The Leu72Met (+408C>A) polymorphic variant of the preproghrelin, the gene for the ghrelin precursor, has been linked to obesity, diabetes and metabolic syndrome.
|
17884032 |
2008 |
|
rs696217
|
GHRL;GHRLOS
|
Hypertensive disease
|
|
0.020 |
GeneticVariation |
BEFREE |
The Leu72Met polymorphism was not associated with hypertension, diabetes, dyslipidemia, the number of diseased vessels, plasma total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol or fasting glucose levels in CAD patients.
|
17884032 |
2008 |
|
rs696217
|
GHRL;GHRLOS
|
Diabetes Mellitus
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequency of the Leu72Met polymorphism in diabetic nephropathy was significantly lower in patients with renal dysfunction (15.9%, P < 0.01) than in patients with normal renal function (42.0%) or in the diabetes control group (40.6%).
|
16793966 |
2006 |