rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs6010620 (RTEL1), rs4977756 (CDKN2A/B), and rs498872 (PHLDB1) are associated with glioma risk in the Portuguese population and these data may contribute to understanding gliomas etiology.
|
31721021 |
2020 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
|
30714141 |
2019 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma.
|
25227808 |
2014 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, there was a significant association between RTEL1 rs6010620 polymorphism and glioma risk in all fo</span>ur genetic models (GG vs. AA: OR=1.87, 95 % CI=1.60-2.18, P heterogeneity=0.552; GA vs. AA: OR=1.30, 95 % CI=1.16-1.46, P heterogeneity=0.495; dominant model-GG+GA vs. AA: OR=1.46, 95 % CI=1.31-1.63, P heterogeneity=0.528; recessive model-GG vs. GA+AA: OR=1.36, 95 % CI=1.27-1.46, P heterogeneity=0.093).
|
24523019 |
2014 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASDB |
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
|
24908248 |
2014 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the RTEL1 rs6010620 polymorphism may be a risk factor for glioma.
|
25556444 |
2014 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
|
24908248 |
2014 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
After Bonferroni correction for multiple comparisons, only one marker was statistically significantly associated with glioma risk, rs6010620 (ORtrend for the minor (A) allele, 0.39; 95% CI: 0.25-0.61; Bonferroni adjusted ptrend , 1.7 × 10(-4) ).
|
23115063 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Four of the five SNPs previously reported by others were statistically significantly associated with increased risk of glioma in our study (rs2736100, rs4295627, rs4977756, and rs6010620); rs498872 was not associated with glioma in our study.
|
23903690 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Case-control analyses stratified into 4 molecular classes (defined by 1p-19q status, IDH mutation, and EGFR amplification) showed an association of rs4295627 and rs498872 with IDH-mutated gliomas (P < 10(-3)) and rs2736100 and rs6010620 with IDH wild-type gliomas (P < 10(-3) and P = .03).
|
23161787 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Two single variants, the genotypes of "GG" of rs</span>6010620 and "CC" of rs2297440 (rs6010620</span> and r</span>s2297440) in the RTEL1 gene, together with two haplotypes of GCT and ATT, were identified to be associated with glioma development.
|
23683922 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of glioma and meta-analysis.
|
22886559 |
2012 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have identified the susceptibility single nucleotide polymorphisms (SNPs) of glioma at chromosome 20q13.33, and the replication study conducted among Chinese Han population also confirmed the susceptibility locus rs6010620 is located in this region.
|
22387365 |
2012 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of glioma and meta-analysis.
|
22886559 |
2012 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)).
|
21350045 |
2011 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
GWASCAT |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population.
|
21920947 |
2011 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872).
|
20212223 |
2010 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk.
|
20462933 |
2010 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk.
|
20847058 |
2010 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
|
19578366 |
2009 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASCAT |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
G |
0.900 |
GeneticVariation |
GWASDB |
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
|
19578366 |
2009 |