DisGeNET - a database of gene-disease associations

PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, 5290

N. diseases: 1511; N. variants: 83

Disease: Non-Small Cell Lung Carcinoma ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors.

21430269

2011

dbSNP:

rs121913273

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors.

21430269

2011

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors.

21430269

2011

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors.

21430269

2011

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

High frequency of mutations of the PIK3CA gene in human cancers.

15016963

2004

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

High frequency of mutations of the PIK3CA gene in human cancers.

15016963

2004

dbSNP:

rs121913273

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

High frequency of mutations of the PIK3CA gene in human cancers.

15016963

2004

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

High frequency of mutations of the PIK3CA gene in human cancers.

15016963

2004

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

High frequency of mutations of the PIK3CA gene in human cancers.

15016963

2004

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

22162589

2012

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

22162589

2012

dbSNP:

rs121913273

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

22162589

2012

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

22162589

2012

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

22162589

2012

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

15647370

2005

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

15647370

2005

dbSNP:

rs121913273

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

15647370

2005

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

15647370

2005

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

15647370

2005

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

PIK3CA mutation status in Japanese lung cancer patients.

16930767

2006

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

PIK3CA mutation status in Japanese lung cancer patients.

16930767

2006

dbSNP:

rs121913273

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

PIK3CA mutation status in Japanese lung cancer patients.

16930767

2006

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

PIK3CA mutation status in Japanese lung cancer patients.

16930767

2006

dbSNP:

rs121913279

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

PIK3CA mutation status in Japanese lung cancer patients.

16930767

2006

dbSNP:

rs104886003

Entrez Id:	5290
Gene Symbol:	PIK3CA

PIK3CA

CUI:	C0007131
Disease:

Non-Small Cell Lung Carcinoma

0.700

CausalMutation

CLINVAR

Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.

20453058

2010