DisGeNET - a database of gene-disease associations

UGT1A6, UDP glucuronosyltransferase family 1 member A6, 54578

N. diseases: 115; N. variants: 229

Disease: Bilirubin measurement ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs10178992

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs10178992

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs10178992

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10179091

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs10179091

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

19419973

2009

dbSNP:

rs10179091

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

23371916

2013

dbSNP:

rs10179091

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10179091

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs1042640

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54658;54659;339766
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3;MROH2A

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3;MROH2A

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10445704

Entrez Id:	54575;54576;54577;54578;54600
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs10445704

Entrez Id:	54575;54576;54577;54578;54600
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs1054804

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10929301

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs10929301

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs10929301

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs10929302

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015

dbSNP:

rs10929302

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASDB

In addition, SNP rs10929302 located in phenobarbital response enhancer module was significantly associated with bilirubin level with a P-value of 1.37 × 10(-11); this enhancer module is believed to have a critical role in phenobarbital treatment of hyperbilirubinemia.

22085899

2012

dbSNP:

rs10929303

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54658;54659;339766
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3;MROH2A

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3;MROH2A

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs1105879

Entrez Id:	54575;54576;54577;54578;54600
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

23642732

2013

dbSNP:

rs1105879

Entrez Id:	54575;54576;54577;54578;54600
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs1105880

Entrez Id:	54575;54576;54577;54578;54600
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

23371916

2013

dbSNP:

rs1105880

Entrez Id:	54575;54576;54577;54578;54600
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A9

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

22085899

2012

dbSNP:

rs11563251

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54658;54659
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11568318

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11673726

Entrez Id:	54575;54576;54577;54578;54579;54600;54657;54659;100286922
Gene Symbol:	UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A3;LOC100286922

CUI:	C0344395
Disease:

Bilirubin measurement

0.800

GeneticVariation

GWASCAT

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

26148204

2015