BTG4, BTG anti-proliferation factor 4, 54766

N. diseases: 9; N. variants: 2
Disease: Colorectal Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4938723
rs4938723
Entrez Id: 54766;407041;407042;728196
Gene Symbol: BTG4;MIR34B;MIR34C;LOC728196
BTG4;MIR34B;MIR34C;LOC728196
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.070 GeneticVariation BEFREE These findings indicate that the miR-34b/c rs4938723T > C polymorphism is an independent variable and associated with a decreased risk of CRC in Chinese population. 31349954 2019
dbSNP: rs4938723
rs4938723
Entrez Id: 54766;407041;407042;728196
Gene Symbol: BTG4;MIR34B;MIR34C;LOC728196
BTG4;MIR34B;MIR34C;LOC728196
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.070 GeneticVariation BEFREE CONCLUSIONS Current meta-analysis suggested that rs4938723 polymorphism was potentially associated with hepatocellular carcinoma risk, but this polymorphism had a decreased association for susceptibility to esophageal cancer, leukemia, and colorectal cancer. 30286050 2018
dbSNP: rs4938723
rs4938723
Entrez Id: 54766;407041;407042;728196
Gene Symbol: BTG4;MIR34B;MIR34C;LOC728196
BTG4;MIR34B;MIR34C;LOC728196
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.070 GeneticVariation BEFREE After stratifying by ethnicity and cancer type, genotype CT of rs4938723 was significantly association with an increased cancer risk in Asian population (P(h)=0.187, OR=1.10, 95%CI=1.01-1.20), allele C and genotype CT were significantly positive associated with hepatocellular cancer (P(h)=0.113, OR=1.11, 95%CI=1.01-1.23 for C vs. T; P(h)=0.121, OR=1.19, 95%CI=1.03-1.37 for CT vs. TT), but rs4938723 was negative associated with risk of colorectal cancer (P(h)=0.342, OR=0.66, 95%CI=0.47-0.92 for CC vs. TT; P(h)=0.519, OR=0.67, 95%CI=0.49-0.93 for CC vs. CT/TT; P(h)=0.443, OR=0.71, 95%CI=0.51-0.99 for CC/TT vs. CT). 25475831 2015
dbSNP: rs4938723
rs4938723
Entrez Id: 54766;407041;407042;728196
Gene Symbol: BTG4;MIR34B;MIR34C;LOC728196
BTG4;MIR34B;MIR34C;LOC728196
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.070 GeneticVariation BEFREE This rs4938723 SNP showed an opposite tendency orientation between the hepatocellular cancer and colorectal cancer risks. 25201061 2014
dbSNP: rs4938723
rs4938723
Entrez Id: 54766;407041;407042;728196
Gene Symbol: BTG4;MIR34B;MIR34C;LOC728196
BTG4;MIR34B;MIR34C;LOC728196
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.070 GeneticVariation BEFREE The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer. 25227823 2014
dbSNP: rs4938723
rs4938723
Entrez Id: 54766;407041;407042;728196
Gene Symbol: BTG4;MIR34B;MIR34C;LOC728196
BTG4;MIR34B;MIR34C;LOC728196
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.070 GeneticVariation BEFREE The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, but the SNP TP53 Arg72Pro CC with DM showed a protective effect against CRC. 24337371 2014
dbSNP: rs4938723
rs4938723
Entrez Id: 54766;407041;407042;728196
Gene Symbol: BTG4;MIR34B;MIR34C;LOC728196
BTG4;MIR34B;MIR34C;LOC728196
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.070 GeneticVariation BEFREE These findings indicate that the rs4938723 in the promoter region of pri-miR-34b/c was a protective factor for the development of CRC. 23183747 2013