|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
Statistically significant results found for the various QTs and SNPs were: rs3774933, rs230528, rs230521, rs1005819 and rs1609798 (intronic, NFKB1) with APOB; rs5361 (Missense, R greatr than S, SELE) and rs4648004 (Intronic, NFKB1) with FBG; rs4220 (Missense, K greater than R, FGB) with HCY; and rs3025035 (Intronic, VEGFA) with CHOL-H. SNPs in SELE, VEGFA, FGB and NFKB1 genes impact significantly on levels of quantitative precursors of CAD in Marwaris.
|
22116284 |
2011 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
The interaction of classical risk factors for CAD with S128R polymorphism in our study population showed that the significant determinants of coronary artery disease were presence of diabetes, hypertension, smoking habit, elevated serum triglycerides and low HDL.
|
19942746 |
2009 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
In the present study, we assessed the possible interactive effect of DM2 and E-selectin S128R polymorphism with respect to its predisposing individuals to CAD, using as a study model a population of 1,112 patients and 427 angiographed controls of Saudi origin.
|
17578587 |
2007 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
Among the Saudi population, The E-selectin p. S128R (g. A561C) polymorphism was associated with angiographic CAD in Univariate analysis, but lost its association in multivariate analysis.
|
16756647 |
2006 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China.
|
16061120 |
2005 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
In subjects suffering from diabetes mellitus type 2 the E-selectin S128R polymorphism is not associated with coronary artery disease nor with an increased risk for myocardial infarction.
|
15013273 |
2003 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
The Ser128Arg polymorphism of E-selectin was analyzed in 101 (derivation) and 92 (validation) CAD patients.
|
12036529 |
2002 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
After controlling for other CAD risk factors (plasma total cholesterol, triglyceride, LDL-apolipoprotein B. cigarette smoking and the S128R mutation) by multiple logistic analysis, the G98T mutation in the E-selectin gene was still a significant predictor of premature CAD [p = 0.022, odds ratio (95%, CI)= 3.58 (1.20-10.67)].
|
11168027 |
2001 |