PRSS1, serine protease 1, 5644

N. diseases: 117; N. variants: 33
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10273639
rs10273639
Entrez Id: 5644
Gene Symbol: PRSS1
PRSS1
CUI: C0030305
Disease:
Pancreatitis
0.820 GeneticVariation BEFREE Effects of PRSS1-PRSS2 rs10273639, CLDN2 rs7057398 and MORC4 rs12688220 polymorphisms on individual susceptibility to pancreatitis: A meta-analysis. 31163246 2020
dbSNP: rs10273639
rs10273639
Entrez Id: 5644
Gene Symbol: PRSS1
PRSS1
CUI: C0030305
Disease:
Pancreatitis
0.820 GeneticVariation BEFREE While rs62228256 was not validated as a risk factor (<i>P</i>=0.77), both rs13228878 (<i>P</i>=0.03) and rs10273639 (<i>P</i>=0.04) were. rs13228878 and rs10273639 are in high linkage disequilibrium (r<sup>2</sup>=0.94) and associated with elevated expression of the <i>PRSS1</i> gene, which encodes for trypsinogen, and are known risk variants for alcohol-associated and sporadic pancreatitis in adults. 30467200 2019
dbSNP: rs10273639
rs10273639
Entrez Id: 5644
Gene Symbol: PRSS1
PRSS1
CUI: C0030305
Disease:
Pancreatitis
C 0.820 GeneticVariation GWASCAT Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. 23143602 2012
dbSNP: rs10273639
rs10273639
Entrez Id: 5644
Gene Symbol: PRSS1
PRSS1
CUI: C0030305
Disease:
Pancreatitis
C 0.820 GeneticVariation GWASDB Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. 23143602 2012