PRSS2, serine protease 2, 5645

N. diseases: 66; N. variants: 14
Disease: Pancreatitis, Chronic ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs61734659
rs61734659
Entrez Id: 5645
Gene Symbol: PRSS2
PRSS2
CUI: C0149521
Disease:
Pancreatitis, Chronic 		0.020 GeneticVariation BEFREE The p.G191R frequency was lower in patients with alcoholic (0.9%; p = 0.015; OR, 0.132; 95% CI, 0.022 to 0.779) and idiopathic (1.0%; p = 0.025; OR, 0.144; 95% CI, 0.025 to 0.851) chronic pancreatitis than that in healthy controls. 19052022 2009
dbSNP: rs61734659
rs61734659
Entrez Id: 5645
Gene Symbol: PRSS2
PRSS2
CUI: C0149521
Disease:
Pancreatitis, Chronic 		0.020 GeneticVariation BEFREE In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis. 16699518 2006