PTEN, phosphatase and tensin homolog, 5728

N. diseases: 1349; N. variants: 384
Disease: Malignant Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs701848
rs701848
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006826
Disease:
Malignant Neoplasms 		0.030 GeneticVariation BEFREE Moreover, the SNP rs701848 CC, TC genotype showed significantly increased the overall cancer risk both in dominant model [CC/TC vs. TT: OR(95% CI) = 1.25(1.15, 1.36)] and recessive model [CC vs. 29259266 2017
dbSNP: rs701848
rs701848
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006826
Disease:
Malignant Neoplasms 		0.030 GeneticVariation BEFREE This meta-analysis indicates that the <i>PTEN</i> rs701848 (CC) and rs2735343 (GG) polymorphisms are associated with increased cancer risk in Asian subjects. 29221206 2017
dbSNP: rs701848
rs701848
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0006826
Disease:
Malignant Neoplasms 		0.030 GeneticVariation BEFREE Epidemiologic studies suggested that mutations of the PI3K/PTEN/AKT pathway genes are associated with cancer risk, yet no data are available for PTEN rs701848, PIK3CA rs2699887, and AKT1 rs2494752 polymorphism and breast cancer(BC) risk. 28423632 2017