PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.050 GeneticVariation BEFREE Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038). 29321183 2018
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.050 GeneticVariation BEFREE Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038). 29321183 2018
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.050 GeneticVariation BEFREE Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis. 24789723 2015
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.050 GeneticVariation BEFREE COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01]. 25433948 2015
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.050 GeneticVariation BEFREE Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis. 24789723 2015
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.050 GeneticVariation BEFREE COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01]. 25433948 2015
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.050 GeneticVariation BEFREE This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. 25214704 2014
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.050 GeneticVariation BEFREE This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. 25214704 2014
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.050 GeneticVariation BEFREE In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer. 20033767 2010
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.050 GeneticVariation BEFREE In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer. 20033767 2010
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038). 29321183 2018
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.040 GeneticVariation BEFREE Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038). 29321183 2018
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0600139
Disease:
Prostate carcinoma
0.040 GeneticVariation BEFREE The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis. 26535654 2015
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0376358
Disease:
Malignant neoplasm of prostate
0.040 GeneticVariation BEFREE The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis. 26535654 2015
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE In this case-control study, three sequence variants rs689465, rs689466, rs20417 in the promoter region of COX-2 were screened to evaluate the association with breast cancer risk. 24789723 2015
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.040 GeneticVariation BEFREE In contrast, COX-2 rs5275, rs689466, rs2206593 and rs5277 polymorphisms might be not associated with the risk of breast cancer. 25433948 2015
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.040 GeneticVariation BEFREE In this case-control study, three sequence variants rs689465, rs689466, rs20417 in the promoter region of COX-2 were screened to evaluate the association with breast cancer risk. 24789723 2015
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE In contrast, COX-2 rs5275, rs689466, rs2206593 and rs5277 polymorphisms might be not associated with the risk of breast cancer. 25433948 2015
dbSNP: rs5275
rs5275
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0678222
Disease:
Breast Carcinoma
0.040 GeneticVariation BEFREE Associations between the 8473T>C polymorphism (rs5275) in the cyclooxygenase-2 (COX-2) gene and breast cancer (BC) risk are still inconclusive and ambiguous. 25520090 2014
dbSNP: rs5275
rs5275
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE The rs5275 polymorphism had no association with breast cancer risk. 25214704 2014
dbSNP: rs5275
rs5275
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0678222
Disease:
Breast Carcinoma
0.040 GeneticVariation BEFREE The rs5275 polymorphism had no association with breast cancer risk. 25214704 2014
dbSNP: rs5275
rs5275
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE Associations between the 8473T>C polymorphism (rs5275) in the cyclooxygenase-2 (COX-2) gene and breast cancer (BC) risk are still inconclusive and ambiguous. 25520090 2014
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0678222
Disease:
Breast Carcinoma
0.040 GeneticVariation BEFREE This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. 25214704 2014
dbSNP: rs689466
rs689466
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians. 25214704 2014
dbSNP: rs20417
rs20417
Entrez Id: 5743;103752588
Gene Symbol: PTGS2;PACERR
PTGS2;PACERR
CUI: C0600139
Disease:
Prostate carcinoma
0.040 GeneticVariation BEFREE When all groups were pooled, we did not detect a significant association of rs20417 polymorphism with prostate cancer risk. 22782583 2012