RAD51C, RAD51 paralog C, 5889

N. diseases: 162; N. variants: 96
Disease: Neoplastic Syndromes, Hereditary ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes. 28829762 2017
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy. 26678223 2016
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. 25292178 2015
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. 26354865 2015
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Genetic testing for RAD51C mutations: in the clinic and community. 25470109 2015
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers. 24993905 2014
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. 23438602 2013
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families. 22451500 2012
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183 2012
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010