RAD51C, RAD51 paralog C, 5889

N. diseases: 162; N. variants: 96
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs267606997
rs267606997
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O
A 0.800 GeneticVariation CLINVAR Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. 26354865 2015
dbSNP: rs267606997
rs267606997
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O
0.800 GeneticVariation UNIPROT Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
dbSNP: rs267606998
rs267606998
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
0.800 GeneticVariation UNIPROT Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
C 0.800 GeneticVariation CLINVAR Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
0.800 GeneticVariation UNIPROT Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787 2014
dbSNP: rs267606997
rs267606997
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O
A 0.800 GeneticVariation CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183 2012
dbSNP: rs267606998
rs267606998
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
0.800 GeneticVariation UNIPROT Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. 21990120 2012
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
C 0.800 GeneticVariation CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183 2012
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
0.800 GeneticVariation UNIPROT Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. 21990120 2012
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
C 0.800 GeneticVariation CLINVAR Germline RAD51C mutations confer susceptibility to ovarian cancer. 22538716 2012
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
C 0.800 GeneticVariation CLINVAR Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families. 22451500 2012
dbSNP: rs267606997
rs267606997
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O
A 0.800 GeneticVariation CLINVAR Mutation of the RAD51C gene in a Fanconi anemia-like disorder. 20400963 2010
dbSNP: rs267606997
rs267606997
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O
0.800 GeneticVariation UNIPROT Mutation of the RAD51C gene in a Fanconi anemia-like disorder. 20400963 2010
dbSNP: rs267606998
rs267606998
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
0.800 GeneticVariation UNIPROT Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
C 0.800 GeneticVariation CLINVAR Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
0.800 GeneticVariation UNIPROT Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. 20400964 2010
dbSNP: rs267606997
rs267606997
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O
A 0.800 CausalMutation CLINVAR
dbSNP: rs267606998
rs267606998
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
T 0.800 SusceptibilityMutation CLINVAR
dbSNP: rs267606999
rs267606999
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C3150659
Disease:
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3
C 0.800 SusceptibilityMutation CLINVAR
dbSNP: rs1327086366
rs1327086366
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0677776
Disease:
Hereditary Breast and Ovarian Cancer Syndrome
A 0.700 GeneticVariation CLINVAR Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. 29922827 2018
dbSNP: rs387907159
rs387907159
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0677776
Disease:
Hereditary Breast and Ovarian Cancer Syndrome
T 0.700 CausalMutation CLINVAR Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. 29922827 2018
dbSNP: rs767796996
rs767796996
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0677776
Disease:
Hereditary Breast and Ovarian Cancer Syndrome
A 0.700 GeneticVariation CLINVAR Mutational analysis of RAD51C and RAD51D genes in hereditary breast and ovarian cancer families from Murcia (southeastern Spain). 29409816 2018
dbSNP: rs1555605074
rs1555605074
Entrez Id: 5889;105371843
Gene Symbol: RAD51C;LOC105371843
RAD51C;LOC105371843
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary
T 0.700 GeneticVariation CLINVAR Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2. 27616075 2017
dbSNP: rs1555605074
rs1555605074
Entrez Id: 5889;105371843
Gene Symbol: RAD51C;LOC105371843
RAD51C;LOC105371843
CUI: C3150653
Disease:
FANCONI ANEMIA, COMPLEMENTATION GROUP O
T 0.700 GeneticVariation CLINVAR Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2. 27616075 2017
dbSNP: rs200293302
rs200293302
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary
T 0.700 CausalMutation CLINVAR Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. 28588062 2017