RAD51D, RAD51 paralog D, 5892

N. diseases: 36; N. variants: 75
Disease: Malignant Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs370228071
rs370228071
Entrez Id: 5892;100529207
Gene Symbol: RAD51D;RAD51L3-RFFL
RAD51D;RAD51L3-RFFL
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE This study identifies c.620C>T;p.S207L as the first bona fide pathogenic <i>RAD51D</i> missense cancer susceptibility allele and supports the use of targeted PARP-inhibitor therapies in ovarian cancer patients carrying deleterious missense <i>RAD51D</i> variants.<i>Cancer Res; 77(16); 4517-29.©2017 AACR</i>. 28646019 2017