REN, renin, 5972

N. diseases: 721; N. variants: 25
Disease: Hypertensive disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs777208537
rs777208537
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0020538
Disease:
Hypertensive disease 		0.030 GeneticVariation BEFREE In addition to these polymorphisms, the T(-344)C polymorphism in the promoter of the aldosterone synthase gene (CYP11B2) and the C825T polymorphism of the G-protein beta3 subunit gene (GNB3) are considered candidates for the genetic risk of salt-sensitive hypertension. 12924618 2003
dbSNP: rs777208537
rs777208537
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0020538
Disease:
Hypertensive disease 		0.030 GeneticVariation BEFREE A functional single-nucleotide variant of the gene encoding the beta3 subunit of heterotrimeric G proteins (Gbeta3 C825T), associated with enhanced G-protein activation and increased activity of the sodium-proton exchanger (NHE1), has been implicated in the development of hypertension. 10930182 2000
dbSNP: rs777208537
rs777208537
Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0020538
Disease:
Hypertensive disease 		0.030 GeneticVariation BEFREE Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks. 10601117 1999