Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs210967
rs210967
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0025295
Disease:
Meningitis, Pneumococcal
0.700 GeneticVariation GWASCAT Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis. 31092817 2019
dbSNP: rs210966
rs210966
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0201973
Disease:
Creatine kinase measurement
0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs6913494
rs6913494
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis
0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs6913494
rs6913494
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C1837461
Disease:
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs17632578
rs17632578
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute
C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs1894674
rs1894674
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute
C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs2157535
rs2157535
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute
G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs2301485
rs2301485
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute
A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs3798379
rs3798379
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute
T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder)
T 0.700 GeneticVariation CLINVAR Acquired resistance to crizotinib from a mutation in CD74-ROS1. 23724914 2013
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0152013
Disease:
Adenocarcinoma of lung (disorder)
T 0.700 CausalMutation CLINVAR
dbSNP: rs1444274116
rs1444274116
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0278701
Disease:
Gastric Adenocarcinoma
0.700 GeneticVariation UNIPROT
dbSNP: rs61743088
rs61743088
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C4021085
Disease:
Abnormality of brain morphology
G 0.700 GeneticVariation CLINVAR
dbSNP: rs776274768
rs776274768
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0349588
Disease:
Short stature
A 0.700 CausalMutation CLINVAR
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.030 GeneticVariation BEFREE Non-small-cell lung cancer (NSCLC) patients harboring ALK or ROS1 rearrangements invariably acquire resistance to the first- and second-generation tyrosine kinase inhibitors (TKIs), most notably ALK G1202R and ROS1 G2032R. 30683630 2019
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.030 GeneticVariation BEFREE Development of the acquired ROS1 G2032R mutation has been reported as a resistant mechanism to ROS1 inhibitors in ROS1-rearranged (ROS1<sup>+</sup>) NSCLC patients. 29477381 2018
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.030 GeneticVariation BEFREE In an ongoing phase I trial, the ALK tyrosine kinase inhibitor (TKI) crizotinib shows remarkable initial responses in patients with non-small cell lung cancer (NSCLC) harboring ROS1 fusions; however, cancers eventually develop crizotinib resistance due to acquired mutations such as G2032R in ROS1. 25351743 2015
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0027651
Disease:
Neoplasms
0.030 GeneticVariation BEFREE The ROS1 G2032R mutation was identified in crizotinib-resistant tumors from one patient. 25688157 2015
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0027651
Disease:
Neoplasms
0.030 GeneticVariation BEFREE In vivo, PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. 25733882 2015
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0027651
Disease:
Neoplasms
0.030 GeneticVariation BEFREE We performed a biopsy of a resistant tumor and identified an acquired mutation leading to a glycine-to-arginine substitution at codon 2032 in the ROS1 kinase domain. 23724914 2013
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0006826
Disease:
Malignant Neoplasms
0.020 GeneticVariation BEFREE Here we report that DS-6051b is effective in treating ROS1- or NTRK-rearranged cancer in preclinical models, including crizotinib-resistant ROS1 positive cancer with secondary kinase domain mutations especially G2032R mutation which is highly resistant to crizotinib as well as lorlatinib and entrectinib, next generation ROS1 inhibitors. 31399568 2019
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C1306459
Disease:
Primary malignant neoplasm
0.020 GeneticVariation BEFREE Here we report that DS-6051b is effective in treating ROS1- or NTRK-rearranged cancer in preclinical models, including crizotinib-resistant ROS1 positive cancer with secondary kinase domain mutations especially G2032R mutation which is highly resistant to crizotinib as well as lorlatinib and entrectinib, next generation ROS1 inhibitors. 31399568 2019
dbSNP: rs1213277193
rs1213277193
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE Non-small-cell lung cancer (NSCLC) patients harboring ALK or ROS1 rearrangements invariably acquire resistance to the first- and second-generation tyrosine kinase inhibitors (TKIs), most notably ALK G1202R and ROS1 G2032R. 30683630 2019
dbSNP: rs1213277193
rs1213277193
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE These results demonstrated how the mutated residues tune the crizotinib response and may assist kinase inhibitor development especially for ALK G1202R, analogous to the ROS1 G2302R and MET G1163R mutations that are also resistant to crizotinib treatment in NSCLC. 31388026 2019
dbSNP: rs1057519788
rs1057519788
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
CUI: C1306459
Disease:
Primary malignant neoplasm
0.020 GeneticVariation BEFREE The effect of the identified drug was assessed in the CD74-ROS1-mutant Ba/F3 cells and crizotinib-resistant patient-derived cancer cells (MGH047) harboring G2032R-mutated CD74-ROS1. 25351743 2015