|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
In 732 Korean community residents ages 65+, diagnosis of depression (Geriatric Mental State Schedule), information on SLEs, and genotypes for 5-HTTLPR and BDNF val66met were ascertained.
|
17482146 |
2007 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression.
|
18852698 |
2010 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.
|
22931410 |
2012 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.
|
19153574 |
2009 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
|
25745134 |
2015 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
No differences in whole blood BDNF was seen in relation to the BDNF Val66Met polymorphism and no significant correlations between whole blood BDNF and HAMD-17 or BDI 21 scores were found.
|
23684538 |
2013 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT.
|
29802070 |
2019 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Plasma brain-derived neurotrophic factor (BDNF) concentration and the <i>BDNF</i> Val66Met polymorphism in suicide: a prospective study in patients with depressive disorder.
|
31308724 |
2019 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.
|
21037213 |
2010 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated with depression and anxiety disorders.
|
20515664 |
2010 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression.
|
17959306 |
2007 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The 5-HT2A A-1438G, 5-HT2A T102C, BDNF Val66Met, and 5-HT1A C-1019G gene polymorphisms might predict the incidence of depression with ABB.
|
24274373 |
2013 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The val66met variant located within the brain-derived neurotrophic factor gene (BDNF) has previously been associated with human neuroticism, a dimension of personality strongly predictive of depressive illness.
|
16043130 |
2005 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF.
|
29280414 |
2019 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to assess the genetic contribution of BDNF Val66Met functional polymorphism to AD-related depression.
|
18179845 |
2009 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The aims of the present case-control study were to investigate the possible role of BDNF Val66Met, 5-HTTLPR and -1438 G/A polymorphisms in the development of coronary artery disease (CAD) in patients with and without depression.
|
19885623 |
2009 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression.
|
30329132 |
2020 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
|
20220593 |
2010 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF val66met polymorphism may modify the association between stroke and depression.
|
17222482 |
2008 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression.
|
19335934 |
2009 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children's lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history.
|
23880378 |
2013 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism might be implicated in the pathogenesis of depression in T2DM by decreasing serum BDNF levels in Han Chinese Subjects.
|
23968401 |
2013 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs759834365
|
BDNF;BDNF-AS
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC.
|
30904785 |
2019 |