BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Disease: Schizophrenia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. 19018714 2008
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia. 18602732 2008
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-methyltransferase (COMT L) is associated with a deficit in attention and aggravation of delusions in schizophrenia. 18596619 2008
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Genotyping of African-American subjects with schizophrenia for five BDNF coding region single nucleotide polymorphisms revealed variance only at the Val66Met</span> allele. 17894414 2008
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Moreover, in a meta-analysis, the Val66Met polymorphism was not associated with schizophrenia, whereas C270T showed a trend for association in a fixed model (p=0.036), but not in a random model (p=0.053). 19406621 2009
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE This study aimed to develop a simple, fast and accurate new method for detecting the Val66Met polymorphism of the BDNF gene in schizophrenia patients using melting-curve analysis and a DNA-specific dye, SYBR Green I. 19530966 2009
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE This study investigated the relationship between two polymorphisms, val66met in the BDNF coding region and -50T/C in the GSK-3beta promoter, and susceptibility to TD among a matched sample of patients having schizophrenia with TD (n = 83), patients with schizophrenia without TD (n = 78), and normal control subjects (n = 93). 19457211 2009
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE With the exception of nominally significant associations between BDNF Val66Met variation and PANSS total, negative, or general scores, no association between the BDNF Val66Met polymorphism and schizophrenia was found. 19359449 2009
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia. 19714565 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Our results suggest that the BDNF Val66Met polymorphism may not contribute directly to the susceptibility to schizophrenia, but to the onset of the disease. 20420877 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Furthermore, the Val66Met polymorphism was not associated with aggressiveness in patients with schizophrenia. 20579509 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task. 20708907 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia. 20957650 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia. 20430595 2010
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) genetic polymorphisms with susceptibility to schizophrenia. 21641949 2011
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE BDNF Val66Met and cannabis use before illness onset were retrospectively assessed in a sample of 585 patients with schizophrenia and their association with age at onset was evaluated. 21305693 2011
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE In the current study, we examined BDNF polymorphisms (G-712A, C270T and Val66Met) in 202 patients with MD and 323 patients with schizophrenia. 21129438 2011
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia. 21248641 2011
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE A single base pair polymorphism (BDNF Val66Met) was reported to be associated with AD and/or schizophrenia, as well as other psychoses, although some studies failed to replicate these findings. 21044653 2011
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism has an important effect on the age of onset of schizophrenia in a gender-specific manner. 21917241 2011
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) genetic polymorphisms with susceptibility to schizophrenia. 21641949 2011
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Our data suggested an association between BDNF Val66Met polymorphism and OCS in Egyptian schizophrenia patients. 22521161 2012
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism. 22362486 2012
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE We have also performed the haplotype analysis with val66met BDNF polymorphism, which is known to be involved in the pathogenesis of schizophrenia. 21710362 2012
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0036341
Disease:
Schizophrenia 		0.100 GeneticVariation BEFREE Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naïve patients with schizophrenia. 22477643 2012