|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine, by meta-analysis, if the Val66Met polymorphism of BDNF influences risk for either schizophrenia, bipolar disorder, or both.
|
17417060 |
2007 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia.
|
16472361 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
This differential response to fetal hypoxia was specific to schizophrenia and was not explained by other obstetric complications or by the BDNF valine (val) to methionine (met) polymorphism at codon 66 (val66met).
|
18486103 |
2008 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies will be required in this area to confirm the effect of the BDNF Val66Met polymorphism in the pathophysiology of schizophrenia and patients' response to antipsychotic drugs, especially in a larger sample size and in different ethnic populations.
|
30312750 |
2018 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
These preliminary findings support the notion of an association of the BDNF-Val66Met-polymorphism with observable alterations in plasticity following cathodal tDCS in schizophrenia patients.
|
25612896 |
2014 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we investigated the association between the Val66Met polymorphism of the gene and schizophrenia in 401 Japanese patients with schizophrenia and 569 controls.
|
16854566 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well.
|
25874530 |
2015 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the Val66Met polymorphism was not associated with aggressiveness in patients with schizophrenia.
|
20579509 |
2010 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients.
|
29898578 |
2018 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia.
|
26603624 |
2016 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.
|
19018714 |
2008 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, which results in deficient activity-dependent secretion of BDNF, is associated with clinical features of schizophrenia.
|
27262112 |
2017 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
To characterize the neurocognitive and brain morphometric phenotypic correlates of the BDNF Val66Met polymorphism and to test the specificity of the BDNF(Met) variant on cognitive dysfunction in schizophrenia.
|
16818862 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task.
|
20708907 |
2010 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment.
|
12951204 |
2003 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
The role of Val66Met polymorphism in BDNF has been shown to play an important role in structural and functional plasticity in schizophrenia.
|
21248641 |
2011 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study tested, in a sample of 94 nuclear families, the hypothesis that the BDNF gene Val66Met polymorphism is associated to SZ and its psychopathologic phenotype using a multidimensional symptom approach.
|
16389585 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
The meta-analysis based on Asian and Caucasian subjects did not give positive result that rs6265 is associated with schizophrenia.
|
17196936 |
2007 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
A single base pair polymorphism (BDNF Val66Met) was reported to be associated with AD and/or schizophrenia, as well as other psychoses, although some studies failed to replicate these findings.
|
21044653 |
2011 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val66 met polymorphism.
|
15719396 |
2005 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association of rs6265 AA + AG × rs1799964 CC + CT with schizophrenia was observed (OR = 1.14, 95%CI: 1.02-1.27; P = .02).
|
29306772 |
2018 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia.
|
20957650 |
2010 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant 2-way interactions were found for Val66Met × PN, 3-way interactions were found for Val66Met × PN × PA, and four-way interactions were found for Val66Met × PN × PA × EN with regard to the excitement scores.Our findings suggested an involvement of BDNF Val66Met polymorphism after ChT in terms of risk for schizophrenia symptoms.
|
29595641 |
2018 |
|
rs6265
|
BDNF;BDNF-AS
|
Schizophrenia
|
|
0.100 |
GeneticVariation |
BEFREE |
We argue that while the Val66Met polymorphism may not be a major risk-conferring agent for the development of schiz</span>ophrenia per se, there is mounting evidence that the polymorphism modulates a range of clinical features of the illness, including age of onset, symptoms, therapeutic responsiveness, neurocognitive function and brain morphology.
|
25562189 |
2015 |