|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the plasma BDNF level did not differ significantly among the three BDNF Val66Met genotypic groups or between patients with A-MCI and those with AD.
|
24253237 |
2014 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD).
|
29896439 |
2018 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
This variant and two previously reported BDNF SNPs (C270T and Val66Met) were genotyped in 295 patients with AD, 108 with AFDs, 96 with posttraumatic stress disorder (PTSD), 84 with schizophrenia, 327 with alcohol and/or drug dependence, and 250 normal control subjects.
|
16649215 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics.
|
28468845 |
2017 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
To compare the results of neuropsychological tests, evoked potentials N200 and P300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD).
|
28833437 |
2018 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Prefrontal cortex BDNF gene expression is associated with aging, rs6265 carrier status, and AD neuropathology in a variant-specific manner that seems to be independent of DNA methylation influences.
|
31127785 |
2019 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD.
|
16627933 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic analysis revealed rs2030324 and rs6265 were associated with aMCI and rs6265 was associated with AD conversion.
|
28387675 |
2017 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment.
|
23769397 |
2013 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.
|
20613678 |
2010 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease.
|
27494844 |
2016 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
|
20097294 |
2010 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met.
|
22699449 |
2012 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggested A allele of rs6265 might increase the risk of AD in Caucasian females and female LOAD patients.
|
24733169 |
2014 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
To study the role of BDNF 196 G>A and 270 C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196 G>A and 270 C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction.
|
16565926 |
2006 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, several reports investigated the association between a single nucleotide polymorphism (Val66Met, rs6265) of the BDNF gene and AD but yielded ambiguous results.
|
17657167 |
2007 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine whether the BDNF Val66Met gene variant interacts with age to predict brain and cognitive measures in healthy volunteers across the adult lifespan in an intermediate phenotype pattern related to AD by examining (1) cortical thickness, (2) fractional anisotropy of white matter tracts (ie, white matter integrity), and (3) episodic memory performance.
|
21300947 |
2011 |
|
rs6265
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD).
|
24475133 |
2014 |
|
rs759834365
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment.
|
23769397 |
2013 |
|
rs759834365
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent association studies have suggested that the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene could play a role in the development of AD.
|
18786162 |
2009 |
|
rs759834365
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics.
|
28468845 |
2017 |
|
rs759834365
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
Our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of AD in the Chinese population and do not support previous findings that homozygosity for the 66Val allele confers an increased risk for AD.
|
14730194 |
2004 |
|
rs759834365
|
BDNF;BDNF-AS
|
Alzheimer's Disease
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF.
|
28720165 |
2017 |