CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0085207
Disease:
Gestational Diabetes
0.010 GeneticVariation BEFREE GDM was significantly associated with genotypes and alleles of the <i>CCL2</i> rs1024611 and rs4586 polymorphisms, while there was no statistically significant association between the <i>CCL5</i> rs2107538, <i>IL4</i> rs2243250, <i>IL15</i> rs2857261, and rs2254514 gene polymorphisms and GDM. 27472286 2017
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031). 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0206623
Disease:
Adenosquamous carcinoma
0.010 GeneticVariation BEFREE Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031). 27145753 2016
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Among the 14 SNPs, CCL2 rs4586 and PDCD1 rs10204525 were found to have an influence on the survival outcomes of the patients with resectable CRC. 27339628 2016
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS). 24820540 2014
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease:
Kidney Failure, Chronic
0.010 GeneticVariation BEFREE Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model). 22817530 2012
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C2316810
Disease:
Chronic kidney disease stage 5
0.010 GeneticVariation BEFREE Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model). 22817530 2012
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0279557
Disease:
Adenosquamous cell lung cancer
0.010 GeneticVariation BEFREE However, minor allele G of rs3760396 polymorphism was significantly associated with increased risk of adenosquamous lung carcinoma with either allelic genetic model (OR = 5.29, P < 0.001), or dominant genetic model (OR = 9.88, P < 0.001), or genotypic model (GC genotype vs. CC genotype, OR = 10.73, P < 0.001). 27145753 2016
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0029408
Disease:
Degenerative polyarthritis
0.010 GeneticVariation BEFREE In conclusion, CCL2 gene polymorphisms (rs1024611 and rs4586) confer susceptibility to OA and may be potential markers for early diagnosis of OA. 31495394 2019
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE In the superoxide dismutase 1 (SOD1)-G93A mouse model of amyotrophic lateral sclerosis (ALS), skeletal muscle is a key target of mutant SOD1 toxicity. 21346327 2011
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE In this analysis adjusted by age and gender, the rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P=0.002), whereas, the rs1024610 TT genotype was associated with decreased risk of T2DM (P=0.035) in premature CAD patients. 26277553 2015
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1956346
Disease:
Coronary Artery Disease
0.010 GeneticVariation BEFREE In this analysis adjusted by age and gender, the rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P=0.002), whereas, the rs1024610 TT genotype was associated with decreased risk of T2DM (P=0.035) in premature CAD patients. 26277553 2015
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242383
Disease:
Age related macular degeneration
0.020 GeneticVariation BEFREE Linear univariate and ANCOVA modeling was performed to show the interaction of rs1024611 with another SNP variant of CCL-2/CCR-2 (rs4586 and rs1799865) and impact of individual genotypes on CCL-2 expression in the context of AMD pathology. 29664944 2018
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis. 23752092 2013
dbSNP: rs3917887
rs3917887
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0022661
Disease:
Kidney Failure, Chronic
0.010 GeneticVariation BEFREE Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy. 25280384 2014
dbSNP: rs3917887
rs3917887
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0011881
Disease:
Diabetic Nephropathy
0.010 GeneticVariation BEFREE Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy. 25280384 2014
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0684249
Disease:
Carcinoma of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs13900
rs13900
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0023283
Disease:
Leishmaniasis, Cutaneous
0.010 GeneticVariation BEFREE Polymorphisms in regulatory regions of the <i>CCL2</i> promoter were analyzed in a pilot cohort of DNA samples from CL patients (cures n=20 and treatment failure n=20), showing putative association of rs13900(C/T) and rs2857656(G/C) with treatment outcome. 31818959 2020
dbSNP: rs13900
rs13900
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0019196
Disease:
Hepatitis C
0.010 GeneticVariation BEFREE Susceptibility to HCV infection is associated with A alleles of both (rs743660 and rs1799864 G/A) of CCR2 while spontaneous clearance of HCV is associated with the C allele of rs13900 of CCL2 and T allele of rs3817655 of CCL5. 30175654 2019
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242383
Disease:
Age related macular degeneration
0.020 GeneticVariation BEFREE The binary logistic regression model is an appropriate tool to predict AMD in the presence of serum CFH, serum CCL2, serum SOD1, polymorphism in CCL2 (rs4586), stress, and comorbidity with high specificity and sensitivity. 23848218 2013
dbSNP: rs2857657
rs2857657
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0409959
Disease:
Osteoarthritis, Knee
0.010 GeneticVariation BEFREE The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. 23211090 2013
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1867743
Disease:
Premature coronary artery atherosclerosis
0.010 GeneticVariation BEFREE The MCP-1 rs2857656 CC genotype is independently associated with carotid artery plaque in African American from families with premature coronary artery disease. 19506371 2009