CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS). 24820540 2014
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Using an ALS mouse model carrying a high copy number of a mutant human superoxide dismutase-1 (SOD1)(G93A) transgene, we investigated the effect of neural induction on the innate therapeutic potential of mesenchymal stem cells (MSCs) in relation to preclinical transplantation parameters. 22472631 2013
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis. 23752092 2013
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE In the superoxide dismutase 1 (SOD1)-G93A mouse model of amyotrophic lateral sclerosis (ALS), skeletal muscle is a key target of mutant SOD1 toxicity. 21346327 2011
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0041330
Disease:
Tuberculosis, Spinal
0.020 GeneticVariation BEFREE We found that the rs1024611 -2518 GG, rs2857656 -362 CC and rs3917887 int1del554-567 del/del homozygous genotypes each were significantly more prevalent in patients than in controls (respective corrected p value [Pc]=0.01, 0.04 and 0.04) Haplotype distribution profile further confirmed this, as the homozygous combination of GCdel haplotype was also found with raised susceptibility to Pott's disease (Pc=0.03). 26626202 2016
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0041330
Disease:
Tuberculosis, Spinal
0.020 GeneticVariation BEFREE The MCP-1-362G/C (rs2857656) polymorphism and blood levels of MCP-1 in patients with spinal TB and healthy subjects were evaluated and compared. 24183600 2014
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE The results showed that variant genotypes of CCL2 rs3760396 and CCL8 rs3138035 were associated with a significantly decreased risk of death for NSCLC (dominant model: adjusted HR=0.65, 95% CI=0.48-0.89 for rs3760396; dominant model: adjusted HR=0.65, 95% CI=0.49-0.86 for rs3138035), while CXCL12 rs1804429 was associated with an increased risk of death for NSCLC (CC vs AA: adjusted HR=6.03, 95% CI=1.44-25.24). 21514686 2011
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242383
Disease:
Age related macular degeneration
0.020 GeneticVariation BEFREE The binary logistic regression model is an appropriate tool to predict AMD in the presence of serum CFH, serum CCL2, serum SOD1, polymorphism in CCL2 (rs4586), stress, and comorbidity with high specificity and sensitivity. 23848218 2013
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242383
Disease:
Age related macular degeneration
0.020 GeneticVariation BEFREE Linear univariate and ANCOVA modeling was performed to show the interaction of rs1024611 with another SNP variant of CCL-2/CCR-2 (rs4586 and rs1799865) and impact of individual genotypes on CCL-2 expression in the context of AMD pathology. 29664944 2018
dbSNP: rs13900
rs13900
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0023283
Disease:
Leishmaniasis, Cutaneous
0.010 GeneticVariation BEFREE Polymorphisms in regulatory regions of the <i>CCL2</i> promoter were analyzed in a pilot cohort of DNA samples from CL patients (cures n=20 and treatment failure n=20), showing putative association of rs13900(C/T) and rs2857656(G/C) with treatment outcome. 31818959 2020
dbSNP: rs13900
rs13900
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0019196
Disease:
Hepatitis C
0.010 GeneticVariation BEFREE Susceptibility to HCV infection is associated with A alleles of both (rs743660 and rs1799864 G/A) of CCR2 while spontaneous clearance of HCV is associated with the C allele of rs13900 of CCL2 and T allele of rs3817655 of CCL5. 30175654 2019
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0036690
Disease:
Septicemia
0.010 GeneticVariation BEFREE This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development. 28472164 2017
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1719672
Disease:
Severe Sepsis
0.010 GeneticVariation BEFREE The rs1024611 AG/GG and rs2857656 GC/CC genotypes were both overrepresented in patients with severe sepsis (both P = 0.0005) and septic shock (P = 0.010 and P = 0.015, respectively) compared to the patients with mild sepsis. 28472164 2017
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1867743
Disease:
Premature coronary artery atherosclerosis
0.010 GeneticVariation BEFREE The MCP-1 rs2857656 CC genotype is independently associated with carotid artery plaque in African American from families with premature coronary artery disease. 19506371 2009
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0243026
Disease:
Sepsis
0.010 GeneticVariation BEFREE This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development. 28472164 2017
dbSNP: rs2857657
rs2857657
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0409959
Disease:
Osteoarthritis, Knee
0.010 GeneticVariation BEFREE The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. 23211090 2013
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0684249
Disease:
Carcinoma of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial
0.010 GeneticVariation BEFREE These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population. 25289731 2015
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE In this analysis adjusted by age and gender, the rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P=0.002), whereas, the rs1024610 TT genotype was associated with decreased risk of T2DM (P=0.035) in premature CAD patients. 26277553 2015
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031). 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0948008
Disease:
Ischemic stroke
0.010 GeneticVariation BEFREE This is a pilot study analysing association of chemokine gene polymorphisms (CXCL1, rs3117604; CXCL2, rs3806792; CCL2, rs2857656 and rs3760396; CCL5, rs2107538) in Korean patients with ischemic stroke (IS) (n = 120) and age-matched controls (n = 267). 23198952 2013
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0206623
Disease:
Adenosquamous carcinoma
0.010 GeneticVariation BEFREE Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031). 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0919267
Disease:
ovarian neoplasm
0.010 GeneticVariation BEFREE These data suggest that MCP-1 rs1024611A/G and rs3760396C/G polymorphisms are associated with increased susceptibility to ovarian cancer, in which rs1024611A/G may increase serum level of MCP-1 in the Chinese population. 25289731 2015