CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Erythropoietin modulates the immune-inflammatory response of a SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS). 24820540 2014
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Using an ALS mouse model carrying a high copy number of a mutant human superoxide dismutase-1 (SOD1)(G93A) transgene, we investigated the effect of neural induction on the innate therapeutic potential of mesenchymal stem cells (MSCs) in relation to preclinical transplantation parameters. 22472631 2013
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis. 23752092 2013
dbSNP: rs746076530
rs746076530
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.040 GeneticVariation BEFREE In the superoxide dismutase 1 (SOD1)-G93A mouse model of amyotrophic lateral sclerosis (ALS), skeletal muscle is a key target of mutant SOD1 toxicity. 21346327 2011
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242383
Disease:
Age related macular degeneration
0.020 GeneticVariation BEFREE Linear univariate and ANCOVA modeling was performed to show the interaction of rs1024611 with another SNP variant of CCL-2/CCR-2 (rs4586 and rs1799865) and impact of individual genotypes on CCL-2 expression in the context of AMD pathology. 29664944 2018
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0041330
Disease:
Tuberculosis, Spinal
0.020 GeneticVariation BEFREE We found that the rs1024611 -2518 GG, rs2857656 -362 CC and rs3917887 int1del554-567 del/del homozygous genotypes each were significantly more prevalent in patients than in controls (respective corrected p value [Pc]=0.01, 0.04 and 0.04) Haplotype distribution profile further confirmed this, as the homozygous combination of GCdel haplotype was also found with raised susceptibility to Pott's disease (Pc=0.03). 26626202 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0041330
Disease:
Tuberculosis, Spinal
0.020 GeneticVariation BEFREE The MCP-1-362G/C (rs2857656) polymorphism and blood levels of MCP-1 in patients with spinal TB and healthy subjects were evaluated and compared. 24183600 2014
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242383
Disease:
Age related macular degeneration
0.020 GeneticVariation BEFREE The binary logistic regression model is an appropriate tool to predict AMD in the presence of serum CFH, serum CCL2, serum SOD1, polymorphism in CCL2 (rs4586), stress, and comorbidity with high specificity and sensitivity. 23848218 2013
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.020 GeneticVariation BEFREE The results showed that variant genotypes of CCL2 rs3760396 and CCL8 rs3138035 were associated with a significantly decreased risk of death for NSCLC (dominant model: adjusted HR=0.65, 95% CI=0.48-0.89 for rs3760396; dominant model: adjusted HR=0.65, 95% CI=0.49-0.86 for rs3138035), while CXCL12 rs1804429 was associated with an increased risk of death for NSCLC (CC vs AA: adjusted HR=6.03, 95% CI=1.44-25.24). 21514686 2011
dbSNP: rs13900
rs13900
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0023283
Disease:
Leishmaniasis, Cutaneous
0.010 GeneticVariation BEFREE Polymorphisms in regulatory regions of the <i>CCL2</i> promoter were analyzed in a pilot cohort of DNA samples from CL patients (cures n=20 and treatment failure n=20), showing putative association of rs13900(C/T) and rs2857656(G/C) with treatment outcome. 31818959 2020
dbSNP: rs13900
rs13900
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0019196
Disease:
Hepatitis C
0.010 GeneticVariation BEFREE Susceptibility to HCV infection is associated with A alleles of both (rs743660 and rs1799864 G/A) of CCR2 while spontaneous clearance of HCV is associated with the C allele of rs13900 of CCL2 and T allele of rs3817655 of CCL5. 30175654 2019
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0029408
Disease:
Degenerative polyarthritis
0.010 GeneticVariation BEFREE In conclusion, CCL2 gene polymorphisms (rs1024611 and rs4586) confer susceptibility to OA and may be potential markers for early diagnosis of OA. 31495394 2019
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0036690
Disease:
Septicemia
0.010 GeneticVariation BEFREE This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development. 28472164 2017
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0243026
Disease:
Sepsis
0.010 GeneticVariation BEFREE This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development. 28472164 2017
dbSNP: rs2857656
rs2857656
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1719672
Disease:
Severe Sepsis
0.010 GeneticVariation BEFREE The rs1024611 AG/GG and rs2857656 GC/CC genotypes were both overrepresented in patients with severe sepsis (both P = 0.0005) and septic shock (P = 0.010 and P = 0.015, respectively) compared to the patients with mild sepsis. 28472164 2017
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0085207
Disease:
Gestational Diabetes
0.010 GeneticVariation BEFREE GDM was significantly associated with genotypes and alleles of the <i>CCL2</i> rs1024611 and rs4586 polymorphisms, while there was no statistically significant association between the <i>CCL5</i> rs2107538, <i>IL4</i> rs2243250, <i>IL15</i> rs2857261, and rs2254514 gene polymorphisms and GDM. 27472286 2017
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0001418
Disease:
Adenocarcinoma
0.010 GeneticVariation BEFREE Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031). 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0206623
Disease:
Adenosquamous carcinoma
0.010 GeneticVariation BEFREE Although rs3760396 polymorphism was not significantly associated with increased risk of adenocarcinoma subtype, it was nominally associated with the pooled outcome of either adenocarcinoma or adenosquamous carcinoma under allelic genetic model (OR = 1.54, P = 0.023) or dominant genetic model (OR = 1.57, P = 0.031). 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0279557
Disease:
Adenosquamous cell lung cancer
0.010 GeneticVariation BEFREE However, minor allele G of rs3760396 polymorphism was significantly associated with increased risk of adenosquamous lung carcinoma with either allelic genetic model (OR = 5.29, P < 0.001), or dominant genetic model (OR = 9.88, P < 0.001), or genotypic model (GC genotype vs. CC genotype, OR = 10.73, P < 0.001). 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0684249
Disease:
Carcinoma of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3760396
rs3760396
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.010 GeneticVariation BEFREE Our study suggested rs3760396 polymorphism of CCL2 is associated not only with prognosis of NSCLC, but also with risk of lung cancer in a subtype-specific manner. 27145753 2016
dbSNP: rs3917887
rs3917887
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0041330
Disease:
Tuberculosis, Spinal
0.010 GeneticVariation BEFREE We found that the rs1024611 -2518 GG, rs2857656 -362 CC and rs3917887 int1del554-567 del/del homozygous genotypes each were significantly more prevalent in patients than in controls (respective corrected p value [Pc]=0.01, 0.04 and 0.04) Haplotype distribution profile further confirmed this, as the homozygous combination of GCdel haplotype was also found with raised susceptibility to Pott's disease (Pc=0.03). 26626202 2016
dbSNP: rs4586
rs4586
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Among the 14 SNPs, CCL2 rs4586 and PDCD1 rs10204525 were found to have an influence on the survival outcomes of the patients with resectable CRC. 27339628 2016