DisGeNET - a database of gene-disease associations

SDHB, succinate dehydrogenase complex iron sulfur subunit B, 6390

N. diseases: 316; N. variants: 130

Disease: PARAGANGLIOMAS 4 ×

Variant: rs587782604 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Germline mutations and genotype-phenotype correlation in Asian Indian patients with pheochromocytoma and paraganglioma.

27539324

2016

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Germline mutations and genotype-phenotype correlation in Asian Indian patients with pheochromocytoma and paraganglioma.

27539324

2016

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice.

25695889

2015

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

[Intrapericardical paraganglioma associated with mutation in succinate dehydrogenase enzyme gene].

24939699

2015

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum.

26259135

2015

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

SDHD immunohistochemistry: a new tool to validate SDHx mutations in pheochromocytoma/paraganglioma.

25405498

2015

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum.

26259135

2015

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

SDHB gene mutation in a carotid body paraganglioma: case report and review of the paraganglioma syndromes.

24509376

2014

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Role of rapid sequence whole-body MRI screening in SDH-associated hereditary paraganglioma families.

23934599

2014

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.

23083876

2012

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma.

20592014

2010

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma.

20592014

2010

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out.

19351833

2009

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out.

19351833

2009

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas.

18382370

2008

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas.

18382370

2008

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Hereditary paraganglioma of the nasopharynx.

20614293

2008

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas.

17200167

2007

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing.

16912137

2006

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Genetic testing in pheochromocytoma or functional paraganglioma.

16314641

2005

dbSNP:

rs587782604

Entrez Id:	6390
Gene Symbol:	SDHB

SDHB

CUI:	C1861848
Disease:

PARAGANGLIOMAS 4

0.700

CausalMutation

CLINVAR

Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.

14500403

2003