SHBG, sex hormone binding globulin, 6462

N. diseases: 368; N. variants: 20
Disease: Diabetes Mellitus, Non-Insulin-Dependent ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799941
rs1799941
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation BEFREE Single-nucleotide polymorphism, rs1799941 in the Sex Hormone-Binding Globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromsø Study. 24327369 2014
dbSNP: rs1799941
rs1799941
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation BEFREE Although SHBG SNPs associated with type 2 diabetes mellitus do not appear to be associated with PCOS status, rs1799941 and rs727428 genotypes are associated with SHBG levels independent of the effects of insulin resistance and obesity. 21252242 2011
dbSNP: rs1799941
rs1799941
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation BEFREE The SHBG SNP rs1799941 was associated with type 2 diabetes [odds ratio (OR) 0.94, 95% CI: 0.91, 0.97; P = 2 x 10(-5)], with the SHBG raising allele associated with reduced risk of type 2 diabetes. 19933169 2010