SLC22A4, solute carrier family 22 member 4, 6583

N. diseases: 90; N. variants: 21
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1050152
rs1050152
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.040 GeneticVariation BEFREE To understand how turmeric may influence the consequences of a genetic predisposition to inappropriate inflammation, we used HEK293 cells to examine the in vitro capacity of turmeric extract and fractions to affect the functionality of two gene variants, solute carrier protein 22 A4 (SLC22A4, rs1050152) and interleukin-10 (IL-10, rs1800896) associated with IBD. 25314644 2014
dbSNP: rs1050152
rs1050152
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.040 GeneticVariation BEFREE The present results replicated the association of the OCTN1 rs1050152 (L503F) variant with CD and IBD overall. 21122496 2010
dbSNP: rs1050152
rs1050152
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.040 GeneticVariation BEFREE The present results replicated the association of the OCTN1 rs1050152 (L503F) variant with CD and IBD overall. 21122496 2010
dbSNP: rs3792876
rs3792876
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.040 GeneticVariation BEFREE We found some evidence for an association of either rs7528684/fcrl3_3 or rs3792876/slc2F2 with RA; however, because the magnitudes of effects were apparently much weaker than those reported in the initial positive reports, and there were substantial levels of inter-study OR heterogeneity, we concluded that additional studies are needed to fully understand the present results. 18087673 2008
dbSNP: rs3792876
rs3792876
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.040 GeneticVariation BEFREE The SLC22A4 polymorphisms slc2F1 (rs2073838) and slc2F2 (rs3792876) are reported to be associated with rheumatoid arthritis (RA) in Japanese, but the associations have not been replicated. 18709696 2008
dbSNP: rs1050152
rs1050152
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.040 GeneticVariation BEFREE To determine whether the TC haplotype is also associated with IBD in a Japanese population, we genotyped L503F and -207G/C variants in Japanese subjects. 16373276 2006
dbSNP: rs3792876
rs3792876
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.040 GeneticVariation BEFREE We found no evidence for an association between RA and either the SNP (rs3792876 [slc2f2]) or the haplotype previously reported to be associated with RA in a Japanese population. 15751072 2005
dbSNP: rs1050152
rs1050152
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0027430
Disease:
Nasal Polyps 		C 0.700 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255 2019
dbSNP: rs12777
rs12777
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12777
rs12777
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0427460
Disease:
Red cell distribution width determination 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12777
rs12777
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0017654
Disease:
Glomerular Filtration Rate 		C 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs419291
rs419291
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs272869
rs272869
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C1519383
Disease:
Smoking Behaviors 		A 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 28443625 2017
dbSNP: rs272869
rs272869
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0037369
Disease:
Smoking 		A 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 28443625 2017
dbSNP: rs6860806
rs6860806
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
CUI: C0678222
Disease:
Breast Carcinoma 		G 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs10075801
rs10075801
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0200638
Disease:
Eosinophil count procedure 		G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs10075801
rs10075801
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0857490
Disease:
Granulocyte count 		G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs10075801
rs10075801
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0200633
Disease:
Neutrophil count (procedure) 		G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs10075801
rs10075801
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0200641
Disease:
Blood basophil count (lab test) 		G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs10075801
rs10075801
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0023508
Disease:
White Blood Cell Count procedure 		G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs11950562
rs11950562
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0200665
Disease:
Platelet mean volume determination (procedure) 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs34301845
rs34301845
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0750880
Disease:
Monocyte count result 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs34301845
rs34301845
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0200637
Disease:
Monocyte count procedure 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs538021413
rs538021413
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0206161
Disease:
Reticulocyte count (procedure) 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs270601
rs270601
Entrez Id: 6583;553103
Gene Symbol: SLC22A4;MIR3936HG
SLC22A4;MIR3936HG
CUI: C0523446
Disease:
Acylcarnitines measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. 26068415 2015