SNCA, synuclein alpha, 6622

N. diseases: 449; N. variants: 66
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE SNCA rs11931074 polymorphism is found to be associated with PD risk and this risk appears to be influenced by genetic status and ethnicity. 31758346 2020
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE In an interaction analysis, SNP rs11931074-PD status interaction was significantly associated with positive α-Syn immunostaining in the ENS (OR = 7.33, 95% CI = 1.58-33.88, P = 0.01). 30424941 2019
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Also blood sample of each participant was genotyped for rs11931074 polymorphism (PD: TT = 19, GT = 32, GG = 11; HC: TT = 10, GT = 25, GG = 12) and then examined to ascertain the influence of different genotypes on regional brain activity with amplitude low-frequency fluctuation analysis (ALFF). 31243602 2019
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Further subgroup analysis showed that PD+RBD patients with rs356219/G exhibited a 30% and 20% decreased risk of progression on the H-Y stage and MoCA score (<i>p</i> = 0.038; <i>p</i> = 0.045). 31244647 2019
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE In the discovery series cohort, we found a 4-loci interaction involving STK11 rs8111699, FCHSD1 rs456998, GSK3B rs1732170, and SNCA rs356219, which was associated with an increased risk of PD (odds ratio = 2.59, P < .001). 31234232 2019
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE The results indicate that there is a significant association between rs356219 polymorphism and PD susceptibility for all genetic models (allelic: OR = 1.377, 95% CI: 1.275-1.487, p = 0.000; homozygous: OR = 1.958, 95% CI: 1.666-2.301, p = 0.000; heterozygous: OR = 1.261, 95% CI: 1.158-1.373, p = 0.000; dominant: OR = 1.431, 95% CI: 1.320-1.550, p = 0.000; recessive: OR = 1.632, 95% CI: 1.431-1.861, p = 0.000), which is consistent with the results of the subgroup analyses on Asians and Caucasians. 31325583 2019
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE The SNCA rs356219-G allele was found to increase the risk of PD in LRRK2 carriers (OR 1.50, 95%CI 1.08-2.01, P = 0.016), and the AAO of AG + GG genotypes was 4 years earlier than AA genotype (P = 0.006). 31041581 2019
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE In conclusion, our meta-analysis further indicates that the SNCA rs11931074 polymorphism contributes to PD susceptibility. 30120622 2018
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE An association with PD was shown for SNPs rs356219, rs11931074, rs356168. 30316070 2018
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE The single-nucleotide polymorphism rs356219 in the α-synuclein (SNCA) gene has been shown to significantly contribute to an earlier age at onset of Parkinson's disease (PD), and regulates SNCA expression in PD brain regions, blood, and plasma. 29505953 2018
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE The association of rs11931074 with decreased risk of PD was also significant. 26732583 2016
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Additionally, the SHEsis software platform was applied for linkage disequilibrium (LD) analysis between rs356182 and another PD-associated synuclein SNP rs356219 we previously reported. 27538639 2016
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Subgroup analysis of patients with both clinical and genetic results demonstrated that after adjusting for age, sex, chronic constipation and cpRBD, rs11931074 TT genotype may increase the risk of hyposmia in PD (OR = 3.24 95% CI = 1.23-8.51, p = 0.017) compared to GG genotype via an additive model. 25921825 2015
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Our results suggest that the rs3822086 (C) allele and rs11931074 (G) allele in SNCA decrease the risk for PD, and SNCA rs11931074 may affect frontal lobe dysfunction of MSA in the Chinese population. 26208350 2015
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE We found that Rep1, rs356165, and rs11931074 in SNCA gene; G2385R in LRRK2 gene; rs4698412 in BST1 gene; rs1564282 in PARK17; and L444P in GBA gene were associated with PD with adjustment of sex and age (p < 0.05) in the analysis of 16 variants. 25623333 2015
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Alpha-synuclein transcript isoforms in three different brain regions from Parkinson's disease and healthy subjects in relation to the SNCA rs356165/rs11931074 polymorphisms. 24418406 2014
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE α-Synuclein rs356219 polymorphisms in patients with Gaucher disease and Parkinson disease. 25111979 2014
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation GWASDB Identification of a novel Parkinson's disease locus via stratified genome-wide association study. 24511991 2014
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression. 23853107 2013
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE This study showed that two SNPs near the promoter region (rs2301134 and rs2301135) of SNCA gene gave the greatest evidence for an association with PD (p ≤ 0.01) and a haplotype block with two SNPs in the 3' UTR (rs356221 and rs11931074) revealed another evidence of association (p ≤ 0.02). 23182315 2013
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Of those, the SNCA SNP rs11931074 showed the most significant association with PD susceptibility (adjusted odds ratio = 1.48; 95% confidence interval = 1.31-1.67; p = 2.20E-10). 23820587 2013
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE Our study provides strong support for the susceptibility role of SNCA rs356219 in sporadic PD in a Han Chinese population from mainland China and the meta-analysis also revealed a similar finding in the Asian population. 23737253 2013
dbSNP: rs11931074
rs11931074
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation GWASDB Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation BEFREE The additive interactions between SNPs rs356219 and rs356220 and smoking with respect to sporadic PD were significant although the multiplicative interactions were not significant. 22425546 2012
dbSNP: rs356219
rs356219
Entrez Id: 6622;105377329
Gene Symbol: SNCA;LOC105377329
SNCA;LOC105377329
CUI: C0030567
Disease:
Parkinson Disease
0.900 GeneticVariation GWASCAT Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. 22438815 2012