SORL1, sortilin related receptor 1, 6653

N. diseases: 103; N. variants: 29
Disease: Alzheimer Disease, Late Onset ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1784933
rs1784933
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset 		0.020 GeneticVariation BEFREE We conclude that rs1784933 and rs1805192 minor alleles, gene- gene interaction between rs1784933 and rs1805192, gene- environment interaction between rs1784933 and alcohol drinking, and haplotype containing the rs1784933- A and rs689021- C alleles are all associated with increased LOAD risk. 28427149 2017
dbSNP: rs1784933
rs1784933
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset 		0.020 GeneticVariation BEFREE Conversely, a SORL1 gene SNP at the rs1784933 locus is associated with LOAD onset, with the A allele being a risk factor. 25450149 2015