SPP1, secreted phosphoprotein 1, 6696

N. diseases: 824; N. variants: 13
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C1561643
Disease:
Chronic Kidney Diseases
0.010 GeneticVariation BEFREE We found that the rs1126616 single nucleotide polymorphism (SNP) of the <i>SPP1</i> gene is independently associated with a higher incidence of CVE in a cohort of CKD patients and that it could be used to predict CVE risk. 31036794 2019
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017661
Disease:
IGA Glomerulonephritis
0.010 GeneticVariation BEFREE The frequency of the minor TT/CT genotypes of rs1126616 was significantly higher in I</span>gAN patients compared to controls (P = 0.0217). 31159229 2019
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017661
Disease:
IGA Glomerulonephritis
0.010 GeneticVariation BEFREE Similarly, the minor (CC/AC) genotypes and the C allele of rs9138 were more frequent in IgAN patients (P = 0.0425 and P = 0.0112, respectively). 31159229 2019
dbSNP: rs17524488
rs17524488
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0038013
Disease:
Ankylosing spondylitis
0.010 GeneticVariation BEFREE The novel 9175th- (exon 7) position polymorphism of <i>OPN</i> and rs17524488 were related to susceptibility to AS in a Chinese population, the rs17524488 G/G genotype may be involved in the pathogenesis of AS, and the precise molecular mechanism underlying the influence of <i>OPN</i> polymorphisms on the development of AS remains to be determined in the further prospective studies. 29581970 2018
dbSNP: rs28357094
rs28357094
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0577631
Disease:
Carotid Atherosclerosis
0.010 GeneticVariation BEFREE We demonstrated an important effect of the SPP1 rs4754 on subclinical markers of carotid atherosclerosis in subjects with T2DM; however, as demonstrated by the multiple linear regression analysis, neither rs4754 nor rs28357094 had an important impact on the progression of subclinical markers of carotid atherosclerosis in subjects with T2DM. 28990744 2018
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.010 GeneticVariation BEFREE When the genetic influence of SPP1 rs4754 TT was excluded, the genetic effects of the SPARC rs1054204, rs3210714 and rs3549 common genotypes on gastric cancer susceptibili</span>ty switched from being risky to beneficial. 28962925 2018
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0004153
Disease:
Atherosclerosis
0.010 GeneticVariation BEFREE Phosphoprotein 1 (osteopontin) gene (rs4754) affects markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus. 28990744 2018
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE Phosphoprotein 1 (osteopontin) gene (rs4754) affects markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus. 28990744 2018
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0577631
Disease:
Carotid Atherosclerosis
0.010 GeneticVariation BEFREE We demonstrated an important effect of the SPP1 rs4754 on subclinical markers of carotid atherosclerosis in subjects with T2DM; however, as demonstrated by the multiple linear regression analysis, neither rs4754 nor rs28357094 had an important impact on the progression of subclinical markers of carotid atherosclerosis in subjects with T2DM. 28990744 2018
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0699791
Disease:
Stomach Carcinoma
0.010 GeneticVariation BEFREE When the genetic influence of SPP1 rs4754 TT was excluded, the genetic effects of the SPARC rs1054204, rs3210714 and rs3549 common genotypes on gastric cancer susceptibili</span>ty switched from being risky to beneficial. 28962925 2018
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0596263
Disease:
Carcinogenesis
0.010 GeneticVariation BEFREE These data reveal an association between the SPP1 rs4754 polymorphism and altered risk of gastric cancer and highlight an important role of the epistatic effects of SPP rs4754 with SPARC polymorphisms in gastric carcinogenesis. 28962925 2018
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003850
Disease:
Arteriosclerosis
0.010 GeneticVariation BEFREE Phosphoprotein 1 (osteopontin) gene (rs4754) affects markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus. 28990744 2018
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0596263
Disease:
Carcinogenesis
0.010 GeneticVariation BEFREE Our findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis. 28095066 2017
dbSNP: rs11730582
rs11730582
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0334037
Disease:
Intestinal metaplasia
0.010 GeneticVariation BEFREE Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). 28685609 2017
dbSNP: rs2853744
rs2853744
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0334037
Disease:
Intestinal metaplasia
0.010 GeneticVariation BEFREE Only in males, but not females, carriage of both GG genotype at rs11730059 and C-G-C haplotype at rs6833161-rs2853744-rs11730582 significantly increased the IM risk (OR: 4.92; 95% CI: 1.65-14.65; p = 0.004). 28685609 2017
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma
0.010 GeneticVariation BEFREE In the case-control study, we found that rs4754-T allele, rs959173-C allele and rs2239144-G allele were the protective allele of NSCLC risk. 28148898 2017
dbSNP: rs9138
rs9138
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0596263
Disease:
Carcinogenesis
0.010 GeneticVariation BEFREE Our findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis. 28095066 2017
dbSNP: rs1126616
rs1126616
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007789
Disease:
Cerebral Palsy
0.010 GeneticVariation BEFREE We found an association between rs1126616 and global CP (corrected allelic P = 0.0006 and genotypic P = 0.0011 after Bonferroni correction). 27114095 2016
dbSNP: rs11728697
rs11728697
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007789
Disease:
Cerebral Palsy
0.010 GeneticVariation BEFREE To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform. 27114095 2016
dbSNP: rs2853744
rs2853744
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007789
Disease:
Cerebral Palsy
0.010 GeneticVariation BEFREE To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform. 27114095 2016
dbSNP: rs2853744
rs2853744
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C2239176
Disease:
Liver carcinoma
0.010 GeneticVariation BEFREE The SNPs associated with HCC risk in patients with cirrhosis and CHB were rs11536889 in TLR4 and rs2853744 in SPP1. 27391584 2016
dbSNP: rs2853744
rs2853744
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0151517
Disease:
Complete atrioventricular block
0.010 GeneticVariation BEFREE The SNPs associated with HCC risk in patients with cirrhosis and CHB were rs11536889 in TLR4 and rs2853744 in SPP1. 27391584 2016
dbSNP: rs2853749
rs2853749
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007789
Disease:
Cerebral Palsy
0.010 GeneticVariation BEFREE To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform. 27114095 2016
dbSNP: rs4754
rs4754
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0007789
Disease:
Cerebral Palsy
0.010 GeneticVariation BEFREE To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform. 27114095 2016
dbSNP: rs1126772
rs1126772
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0003165
Disease:
Anthracosis
0.010 GeneticVariation BEFREE Our results indicate that three functional SNPs (MMP-7 rs10502001, OPN rs11728697 and OPN rs1126772) are associated with an increased risk of CWP in a Chinese population. 26330178 2015