Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0030567
Disease:
Parkinson Disease
0.840 GeneticVariation BEFREE Polymorphism of SREBF1 gene rs11868035 may increase susceptibility to PD in the northeastern Chinese population, while variant of USP25 gene rs2823357 may have no association with susceptibility to PD in northeastern Chinese. 30231795 2019
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0030567
Disease:
Parkinson Disease
0.840 GeneticVariation BEFREE Our results suggested that rs11868035 is likely to be associated with ALS in early-onset or female patients but not with PD or MSA in the Chinese population. 29128630 2018
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0030567
Disease:
Parkinson Disease
0.840 GeneticVariation BEFREE Our findings suggest that rs11868035 may have no association with PD in Chinese population and rs6812193 may have marginal association with PD in male Chinese population. 22531747 2012
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0030567
Disease:
Parkinson Disease
G 0.840 GeneticVariation GWASCAT We discovered two novel, genome-wide significant associations with PD-rs6812193 near SCARB2 (p = 7.6 × 10(-10), OR = 0.84) and rs11868035 near SREBF1/RAI1 (p = 5.6 × 10(-8), OR = 0.85)-both replicated in an independent cohort. 21738487 2011
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0030567
Disease:
Parkinson Disease
0.840 GeneticVariation BEFREE We discovered two novel, genome-wide significant associations with PD-rs6812193 near SCARB2 (p = 7.6 × 10(-10), OR = 0.84) and rs11868035 near SREBF1/RAI1 (p = 5.6 × 10(-8), OR = 0.85)-both replicated in an independent cohort. 21738487 2011
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0030567
Disease:
Parkinson Disease
G 0.840 GeneticVariation GWASDB We discovered two novel, genome-wide significant associations with PD-rs6812193 near SCARB2 (p = 7.6 × 10(-10), OR = 0.84) and rs11868035 near SREBF1/RAI1 (p = 5.6 × 10(-8), OR = 0.85)-both replicated in an independent cohort. 21738487 2011
dbSNP: rs187408367
rs187408367
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0678222
Disease:
Breast Carcinoma
A 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs12941356
rs12941356
Entrez Id: 6720;102465466
Gene Symbol: SREBF1;MIR6777
SREBF1;MIR6777
CUI: C1821417
Disease:
RESTING HEART RATE
G 0.700 GeneticVariation GWASCAT Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality. 27798624 2016
dbSNP: rs4925115
rs4925115
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
dbSNP: rs2297508
rs2297508
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.030 GeneticVariation BEFREE The minor alleles of rs2297508, rs11868035, and rs1889018 (linkage disequilibrium R(2) = 0.6-0.8) associated with a modestly increased risk of type 2 diabetes (rs2297508: OR 1.17 [95% CI 1.05-1.30], P = 0.003), which was confirmed in meta-analyses of all published studies (rs2297508 G-allele: 1.08 [1.03-1.14] per allele, P = 0.001). 18192539 2008
dbSNP: rs2297508
rs2297508
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.030 GeneticVariation BEFREE These findings indicate that the SREBP-1c SNPs rs2297508 and rs11868035 are associated with a significantly increased risk of T2DM and dyslipidemia in the Chinese population. 18692268 2008
dbSNP: rs2297508
rs2297508
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.030 GeneticVariation BEFREE We observed associations of rs2297508 with T2DM prevalence and plasma adiponectin. 17160088 2007
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0524620
Disease:
Metabolic Syndrome X
0.020 GeneticVariation BEFREE Secondary objectives include the analysis of the association between cognitive impairment and psychopathological status and, in a subgroup of patients, the evaluation of the effect of Sterol Regulatory Element Binding Transcription Factor 1 (SREBF-1) rs11868035 genetic polymorphism, previously associated with metabolic alterations, on both cognition and metabolic syndrome. 30581395 2018
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0524620
Disease:
Metabolic Syndrome X
0.020 GeneticVariation BEFREE We followed up 212 randomly selected, nonobese, nondiabetic, insulin-sensitive participants in a population-based study without NAFLD or metabolic syndrome at baseline who were characterized for the common SREBF-1c gene rs11868035 A/G polymorphism, dietary habits, physical activity, adipokine profile, C-reactive protein (CRP), and circulating markers of endothelial dysfunction. 23985808 2013
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE These findings indicate that the SREBP-1c SNPs rs2297508 and rs11868035 are associated with a significantly increased risk of T2DM and dyslipidemia in the Chinese population. 18692268 2008
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.020 GeneticVariation BEFREE The minor alleles of rs2297508, rs11868035, and rs1889018 (linkage disequilibrium R(2) = 0.6-0.8) associated with a modestly increased risk of type 2 diabetes (rs2297508: OR 1.17 [95% CI 1.05-1.30], P = 0.003), which was confirmed in meta-analyses of all published studies (rs2297508 G-allele: 1.08 [1.03-1.14] per allele, P = 0.001). 18192539 2008
dbSNP: rs1889018
rs1889018
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011849
Disease:
Diabetes Mellitus
0.020 GeneticVariation BEFREE The diabetes-associated alleles also associated strongly with a higher plasma glucose at 30 and 120 min and serum insulin at 120 min during an oral glucose tolerance test (all P < 0.006) and the minor allele of rs1889018 with a surrogate measure of insulin sensitivity (P = 0.03). 18192539 2008
dbSNP: rs1889018
rs1889018
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011847
Disease:
Diabetes
0.020 GeneticVariation BEFREE The diabetes-associated alleles also associated strongly with a higher plasma glucose at 30 and 120 min and serum insulin at 120 min during an oral glucose tolerance test (all P < 0.006) and the minor allele of rs1889018 with a surrogate measure of insulin sensitivity (P = 0.03). 18192539 2008
dbSNP: rs1889018
rs1889018
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011847
Disease:
Diabetes
0.020 GeneticVariation BEFREE Also, three other SNPs (rs2236513, rs6502618 and rs1889018), located in the 5' region, were significantly associated with diabetes risk (OR > or =1.21, p< or =0.006). 17019602 2006
dbSNP: rs1889018
rs1889018
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C0011849
Disease:
Diabetes Mellitus
0.020 GeneticVariation BEFREE Also, three other SNPs (rs2236513, rs6502618 and rs1889018), located in the 5' region, were significantly associated with diabetes risk (OR > or =1.21, p< or =0.006). 17019602 2006
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C4511452
Disease:
Sporadic Parkinson disease
0.010 GeneticVariation BEFREE Association analysis of SNP rs11868035 in SREBF1 with sporadic Parkinson's disease, sporadic amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population. 29128630 2018
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0338656
Disease:
Impaired cognition
0.010 GeneticVariation BEFREE Secondary objectives include the analysis of the association between cognitive impairment and psychopathological status and, in a subgroup of patients, the evaluation of the effect of Sterol Regulatory Element Binding Transcription Factor 1 (SREBF-1) rs11868035 genetic polymorphism, previously associated with metabolic alterations, on both cognition and metabolic syndrome. 30581395 2018
dbSNP: rs11868035
rs11868035
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0002736
Disease:
Amyotrophic Lateral Sclerosis
0.010 GeneticVariation BEFREE Our results suggested that rs11868035 is likely to be associated with ALS in early-onset or female patients but not with PD or MSA in the Chinese population. 29128630 2018
dbSNP: rs9902941
rs9902941
Entrez Id: 6720
Gene Symbol: SREBF1
SREBF1
CUI: C1956346
Disease:
Coronary Artery Disease
0.010 GeneticVariation BEFREE The results of this study indicate that variations in the lipid regulatory pathway genes FBXW7 and SREBPs (rs9902941 in SREBP-1, rs7288536 in SREBP-2 and rs10033601 in FBXW7) are associated with CAD in the Uygur Chinese population in Xinjiang, China. 29152152 2017
dbSNP: rs13306741
rs13306741
Entrez Id: 6720;10743
Gene Symbol: SREBF1;RAI1
SREBF1;RAI1
CUI: C0400966
Disease:
Non-alcoholic Fatty Liver Disease
0.010 GeneticVariation BEFREE Four common SNPs (rs62064119, rs2297508, rs11868035 and rs13306741) in the SREBP-1c gene were selected and genotyped in 593 patients with NAFLD and 593 healthy controls. 27572914 2016