rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.790
GeneticVariation
BEFREE
The major aim of this study was to evaluate the performance of anti-BRAF V600E (VE1) antibody in colorectal tumors with and without KRAS mutation.
29127628
2019
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.790
GeneticVariation
BEFREE
BRAF V600E mutation testing of colorectal tumors demonstrating aberrant MLH1 protein expression by IHC was the most common secondary tumor test, with 53% of laboratories performing the test; 15% of laboratories also applied the BRAF V600E test to endometrial tumors with aberrant MLH1 expression despite no evidence for its utility.
30294856
2018
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer.
25989278
2015
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.790
GeneticVariation
BEFREE
Our results support the use of VE1 IHC for identification of colorectal neoplasms harboring the BRAF V600E mutation.
25517872
2015
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.
24163374
2014
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.
24594804
2014
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
23549875
2013
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.790
GeneticVariation
BEFREE
To verify the technical characteristics of the microarray system for the correct identification of the KRAS mutational status at the two hotspot codons 12 and 13 and of the BRAF(V600E ) mutation in colorectal tumor , we selected 75 samples previously characterized by conventional and CO-amplification at Lower Denaturation temperature-PCR (COLD-PCR) followed by High Resolution Melting analysis and direct sequencing.
23536897
2013
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
23251002
2013
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
23845441
2013
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth.
23812671
2013
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Our findings indicated that proteasome inhibition might represent a valuable targeting strategy in BRAF V600E -mutant colorectal tumors .
24107445
2013
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
23325582
2013
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
22180495
2012
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
22448344
2012
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.
22608338
2012
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
22281684
2012
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
BRAF as a target for cancer therapy.
21426297
2011
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.
21163703
2011
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis.
20857202
2011
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.
20350999
2010
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.
20619739
2010
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.
20413299
2010
rs113488022
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
T
0.790
CausalMutation
CLINVAR
Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?
21129611
2010