rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
0.720
GeneticVariation
BEFREE
Twenty-three percent of patients with V600E- and 43% of patients with K601E -mutant melanomas presented with nodal disease at diagnosis compared to just 14% of patients with BRAF wild-type tumors (P = 0.001 and 0.006, respectively).
26643848
2016
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
0.720
GeneticVariation
BEFREE
Melanomas had p.V600E (n = 30), p.V600K (n = 4), p.K601E (n = 1), p.600-601delinsE (n = 1), or no p.V600 mutations (n = 31).
23651150
2014
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
C
0.720
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
C
0.720
GeneticVariation
CLINVAR
Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.
22972589
2013
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
C
0.720
GeneticVariation
CLINVAR
Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.
22048237
2012
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
C
0.720
GeneticVariation
CLINVAR
Improved survival with MEK inhibition in BRAF-mutated melanoma.
22663011
2012
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
C
0.720
GeneticVariation
CLINVAR
Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
21639808
2011
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
C
0.720
GeneticVariation
CLINVAR
Determinants of BRAF mutations in primary melanomas.
14679157
2003
rs121913364
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
melanoma
C
0.720
GeneticVariation
CLINVAR
Mutations of the BRAF gene in human cancer.
12068308
2002