Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs897200
rs897200
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0701807
Disease:
Acute anterior uveitis
0.010 GeneticVariation BEFREE Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain. 24312163 2013
dbSNP: rs10931481
rs10931481
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0271737
Disease:
Addison's disease due to autoimmunity
0.010 GeneticVariation BEFREE We report significant association with alleles of two STAT4 markers in AAD cohorts (rs4274624: P = 0.00016; rs10931481: P = 0.0007). 24614117 2014
dbSNP: rs4274624
rs4274624
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0271737
Disease:
Addison's disease due to autoimmunity
0.010 GeneticVariation BEFREE We report significant association with alleles of two STAT4 markers in AAD cohorts (rs4274624: P = 0.00016; rs10931481: P = 0.0007). 24614117 2014
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0221056
Disease:
Adult type dermatomyositis
0.010 GeneticVariation BEFREE The strongest association was observed in dermatomyositis, with an OR of 3.07 (95% CI; 1.57-6.02) for the carriers of four risk alleles at the two SNP sites, namely, rs1327713 and rs7574865. 24632671 2014
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C4721507
Disease:
Alveolitis, Fibrosing
0.010 GeneticVariation BEFREE Logistic regression analysis showed an additive effect of IRF5 rs2004640, STAT4 rs7574865 and NLRP1 rs8182352 risk alleles on SSc-related FA. 21149496 2011
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0038013
Disease:
Ankylosing spondylitis
0.010 GeneticVariation BEFREE STAT4 rs7574865 G/T was not associated with susceptibility to AS. 23727609 2013
dbSNP: rs897200
rs897200
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0042165
Disease:
Anterior uveitis
0.010 GeneticVariation BEFREE Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain. 24312163 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C2717865
Disease:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
0.010 GeneticVariation BEFREE A case-control study was carried out on IRF5 rs10954213 and STAT4 rs7574865 in 232 Japanese myeloperoxidase (MPO)-ANCA-positive AAV patients, including 177 microscopic polyangiitis and 710 healthy controls. 23985571 2013
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0002874
Disease:
Aplastic Anemia
0.020 GeneticVariation BEFREE The T allele (TT + TG genotypes) of STAT4 variant rs7574865 was associated with increased susceptibility of Chinese people to AA. 22133489 2012
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0002874
Disease:
Aplastic Anemia
0.020 GeneticVariation BEFREE Current study results support that functional STAT4 (rs7574865), IL23R (rs11209032), and STAT3 (rs744166) variants may associate with occurrence, severity, and immunosuppressive outcome of AA in the Han population in southwest China. 29330562 2018
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003864
Disease:
Arthritis
0.010 GeneticVariation BEFREE Our data suggest that patients with early arthritis who are homozygous for the T allele of rs7574865 in STAT4 may develop a more severe form of the disease with increased disease activity and disability. 22937072 2012
dbSNP: rs10181656
rs10181656
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003872
Disease:
Arthritis, Psoriatic
0.020 GeneticVariation BEFREE Significant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)<0.05) was found to seven other loci including PLCL2 (rs4535211, p=1.7×10(-3)); STAT4 (rs10181656, p=3.0×10(-3)) and the AFF3, CD28, CCL21, IL2 and KIF5A loci. 22328738 2012
dbSNP: rs10181656
rs10181656
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003872
Disease:
Arthritis, Psoriatic
0.020 GeneticVariation BEFREE An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports. 27440135 2017
dbSNP: rs1031509
rs1031509
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE Furthermore, having TG + GG genotypes on rs1031509 near STAT4 was associated with 5-times (95% CI, 3.03-8.55) greater odds of asthma diagnosis at the highest B[a]P range, compared to the odds at the reference range. 28807506 2017
dbSNP: rs1400656
rs1400656
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004096
Disease:
Asthma
0.010 GeneticVariation BEFREE Five SNPs, rs3733475A/C (IRF2), rs2069832A/G (IL6), rs2012075G/A (IFNGR2) and rs1400656G/A (STAT4) and rs1805011C/A (IL4RA) were found to be associated with asthma in family based as well as in case-control analyses (P=0.002, P=0.001, P=0.004, P=0.003 and P=0.001, respectively). 25994869 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0241910
Disease:
Autoimmune Chronic Hepatitis
0.010 GeneticVariation BEFREE We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk. 28977835 2017
dbSNP: rs7582694
rs7582694
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0241910
Disease:
Autoimmune Chronic Hepatitis
0.010 GeneticVariation BEFREE We conclude that rs7574865 and rs7582694 in <i>STAT4</i> gene minor alleles, interaction between rs7582694 and rs2476601, and haplotype containing the rs7582694-C and rs7574865-T alleles are associated with increased type 1 AIH risk, but rs2476601 in <i>PTPN22</i> gene minor allele is associated with decreased type 1 AIH risk. 28977835 2017
dbSNP: rs7568275
rs7568275
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C4014795
Disease:
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs7568275
rs7568275
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C4310768
Disease:
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs7568275
rs7568275
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3150797
Disease:
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004364
Disease:
Autoimmune Diseases
0.900 GeneticVariation BEFREE STAT4 polymorphism, rs7574865 is linked to various autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. 27960128 2017
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004364
Disease:
Autoimmune Diseases
0.900 GeneticVariation BEFREE Here we demonstrate for the first time, in a genetically homogeneous population, the association of the STAT4 rs7574865 G/T polymorphism, which has been shown to be associated with these autoimmune diseases, with susceptibility to type 1 diabetes (T1D). 18703106 2008
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004364
Disease:
Autoimmune Diseases
0.900 GeneticVariation BEFREE The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. 26569609 2015
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004364
Disease:
Autoimmune Diseases
0.900 GeneticVariation BEFREE Taking into consideration that the different autoimmune diseases may share some common pathogenetic pathways, the aim of the present study was to evaluate the role of STAT4 rs7574865 polymorphism on acute allograft rejection. 21237270 2011
dbSNP: rs7574865
rs7574865
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0004364
Disease:
Autoimmune Diseases
T 0.900 GeneticVariation GWASDB Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. 21383967 2011