Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C1527336
Disease:
Sjogren's Syndrome
T 0.800 GeneticVariation GWASDB A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C1527336
Disease:
Sjogren's Syndrome
T 0.800 GeneticVariation GWASCAT A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease:
Primary biliary cirrhosis
0.710 GeneticVariation BEFREE We detected significant associations with PBC susceptibility for several STAT4 SNPs (rs10168266; P = 9.4 × 10(-3), rs11889341; P = 1.2 × 10(-3), rs7574865; P = 4.0 × 10(-4), rs8179673; P = 2.0 × 10(-4), and rs10181656; P = 4.2 × 10(-5)). 24648611 2014
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0008312
Disease:
Primary biliary cirrhosis
A 0.710 GeneticVariation GWASCAT A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. 28425483 2017
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.700 GeneticVariation GWASDB Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese. 23028356 2012
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.700 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.700 GeneticVariation GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0027873
Disease:
Neuromyelitis Optica
0.010 GeneticVariation BEFREE After correcting for multiple test comparisons, the minor alleles of four STAT4 SNPs exhibited significant association with increased risk of NMOSD (rs7574865 T, odds ratio [OR] = 1.66, 95% confidence interval [CI] 1.32-2.08, P <sub>corr</sub> = 0.000; rs10181656 G, OR = 1.62, 95% CI 1.29-2.03, P <sub>corr</sub> = 0.000; rs10168266 T, OR = 1.59, 95% CI 1.27-2.00, P <sub>corr</sub> = 0.001; and rs13426947 A, OR = 1.51, 95% CI 1.21-1.90, P <sub>corr</sub> = 0.004). 28852993 2017
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0036421
Disease:
Systemic Scleroderma
0.010 GeneticVariation BEFREE The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc). 23755762 2013
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0034069
Disease:
Pulmonary Fibrosis
0.010 GeneticVariation BEFREE The T-allele carriers of rs7574865 and rs10168266 were strongly associated with the presence of anti-topoisomerase I (ATA) and pulmonary fibrosis in SSc patients, as well as with diffuse cutaneous SSc (dcSSc). 23755762 2013
dbSNP: rs10168266
rs10168266
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0019163
Disease:
Hepatitis B
0.010 GeneticVariation BEFREE Further, haplotype-based association analysis indicated that the haplotype CTCTT, formed by SNPs rs8179673, rs7574865, rs4274624, rs11889341, and rs10168266, was significantly associated with HBV infection (OR 0.87; 95 % CI 0.76, 0.99; P = 0.022) and clearance (OR 0.86; 95 % CI 0.75, 0.99; P = 0.018). 27444301 2016
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3898105
Disease:
Oligoarticular Juvenile Idiopathic Arthritis
G 0.800 GeneticVariation GWASCAT Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3898105
Disease:
Oligoarticular Juvenile Idiopathic Arthritis
0.800 GeneticVariation GWASDB Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C1858558
Disease:
Rheumatoid Arthritis, Systemic Juvenile
G 0.700 GeneticVariation GWASCAT Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C3890205
Disease:
Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative
G 0.700 GeneticVariation GWASCAT Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0748540
Disease:
Scleroderma, Limited
0.700 GeneticVariation GWASCAT Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations. 29293537 2018
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C1384600
Disease:
Systemic onset juvenile chronic arthritis
G 0.700 GeneticVariation GWASCAT Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0003873
Disease:
Rheumatoid Arthritis
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0087031
Disease:
Juvenile-Onset Still Disease
G 0.700 GeneticVariation GWASCAT Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C2931171
Disease:
Juvenile pauciarticular chronic arthritis
G 0.700 GeneticVariation GWASCAT Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. 23603761 2013
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0036421
Disease:
Systemic Scleroderma
0.700 GeneticVariation GWASCAT Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations. 29293537 2018
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0200638
Disease:
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0027121
Disease:
Myositis
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
dbSNP: rs10174238
rs10174238
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0036421
Disease:
Systemic Scleroderma
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019