AURKA, aurora kinase A, 6790

N. diseases: 245; N. variants: 15
Disease: Liver carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C2239176
Disease:
Liver carcinoma 		0.020 GeneticVariation BEFREE Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at <i>AURKA</i> SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the <i>AURKA</i> gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC. 29333101 2018
dbSNP: rs2273535
rs2273535
Entrez Id: 6790
Gene Symbol: AURKA
AURKA
CUI: C2239176
Disease:
Liver carcinoma 		0.020 GeneticVariation BEFREE Our findings suggest that <i>AURKA</i> Ile31Phe</span> may play a role in mediating the susceptibility to HBV-related HCC among Chinese. 28903390 2017