SYK, spleen associated tyrosine kinase, 6850

N. diseases: 229; N. variants: 7
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs290227
rs290227
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0011269
Disease:
Dementia, Vascular
G 0.810 GeneticVariation GWASDB We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene. 23480133 2013
dbSNP: rs290227
rs290227
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0011269
Disease:
Dementia, Vascular
G 0.810 GeneticVariation GWASCAT We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene. 23480133 2013
dbSNP: rs290227
rs290227
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0011269
Disease:
Dementia, Vascular
0.810 GeneticVariation BEFREE We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene. 23480133 2013
dbSNP: rs290986
rs290986
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0026769
Disease:
Multiple Sclerosis
0.800 GeneticVariation GWASCAT Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors. 26920376 2016
dbSNP: rs290986
rs290986
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0026769
Disease:
Multiple Sclerosis
A 0.800 GeneticVariation GWASDB Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088 2011
dbSNP: rs290986
rs290986
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0026769
Disease:
Multiple Sclerosis
A 0.800 GeneticVariation GWASCAT Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088 2011
dbSNP: rs2780701
rs2780701
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C3828530
Disease:
Platelet Component Distribution Width Measurement
G 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs290986
rs290986
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0392885
Disease:
High density lipoprotein measurement
0.700 GeneticVariation GWASCAT Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors. 26920376 2016
dbSNP: rs10821515
rs10821515
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0546837
Disease:
Malignant neoplasm of esophagus
0.700 GeneticVariation GWASDB Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993 2011
dbSNP: rs169724
rs169724
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0596263
Disease:
Carcinogenesis
0.010 GeneticVariation BEFREE We identified one nonsense-mediated mRNA decay transcript variant in the DFNA5 region (rs2237306), associated with Benzo(a)pyrene, as a protective factor (odds ratio = 0.33; p = 0.009) and four harmful (odds ratio > 2.5; p < 0.05) intronic variants, rs182361, rs290974, and rs169724 in SYK and rs1670661 in NELL1 region, involved in genetic susceptibility to tobacco- and HPV-mediated oral oncogenesis. 30091681 2018
dbSNP: rs182361
rs182361
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0596263
Disease:
Carcinogenesis
0.010 GeneticVariation BEFREE We identified one nonsense-mediated mRNA decay transcript variant in the DFNA5 region (rs2237306), associated with Benzo(a)pyrene, as a protective factor (odds ratio = 0.33; p = 0.009) and four harmful (odds ratio > 2.5; p < 0.05) intronic variants, rs182361, rs290974, and rs169724 in SYK and rs1670661 in NELL1 region, involved in genetic susceptibility to tobacco- and HPV-mediated oral oncogenesis. 30091681 2018
dbSNP: rs2991216
rs2991216
Entrez Id: 6850
Gene Symbol: SYK
SYK
CUI: C0024305
Disease:
Lymphoma, Non-Hodgkin
0.010 GeneticVariation BEFREE The most significant SNP associated with NHL maps to the SYK gene (rs2991216, P-trend = 0.00005). 21148756 2011