SYN1, synapsin I, 6853

N. diseases: 80; N. variants: 16
Disease: Premature Menopause ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6609533
rs6609533
Entrez Id: 6853;7076;100616147
Gene Symbol: SYN1;TIMP1;MIR4769
SYN1;TIMP1;MIR4769
CUI: C0025322
Disease:
Premature Menopause 		0.010 GeneticVariation BEFREE The aim of our study was to investigate whether the TIMP polymorphisms TIMP1T > C (rs4898), TIMP1G > A (rs6609533), TIMP2G > C (rs8179090), TIMP2G > A (rs2277698), TIMP3G > A (rs135029), and TIMP4T > C (rs3755724), which regulate matrix metalloproteinases (MMPs), confer a risk for primary ovarian insufficiency (POI) in Korean women (further studies would be required to evaluate the associations between TIMP polymorphisms and POI in other populations). 30583769 2019