TCF3, transcription factor 3, 6929

N. diseases: 244; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1860661
rs1860661
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0019829
Disease:
Hodgkin Disease
0.810 GeneticVariation BEFREE We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. 24920014 2014
dbSNP: rs1860661
rs1860661
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0019829
Disease:
Hodgkin Disease
0.810 GeneticVariation GWASDB We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. 24920014 2014
dbSNP: rs1860661
rs1860661
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0019829
Disease:
Hodgkin Disease
0.810 GeneticVariation GWASCAT We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. 24920014 2014
dbSNP: rs77866734
rs77866734
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0005586
Disease:
Bipolar Disorder
T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. 26503763 2016
dbSNP: rs376780559
rs376780559
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0009402
Disease:
Colorectal Carcinoma
0.700 GeneticVariation UNIPROT
dbSNP: rs879255271
rs879255271
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C4310786
Disease:
AGAMMAGLOBULINEMIA 8, AUTOSOMAL DOMINANT
T 0.700 CausalMutation CLINVAR
dbSNP: rs547275481
rs547275481
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0017638
Disease:
Glioma
0.010 GeneticVariation BEFREE Herein, we provide evidence that preventing phosphorylation of p75(NTR) on S303 by pharmacological inhibition of PKA, or by a mutational strategy (S303G), cripples p75(NTR)-mediated glioma invasion resulting in serine phosphorylation within the C-terminal PDZ-binding motif (SPV) of p75(NTR). 26119933 2016
dbSNP: rs1860661
rs1860661
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0220644
Disease:
Childhood Hodgkin Lymphoma
0.010 GeneticVariation BEFREE We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. 24920014 2014
dbSNP: rs1860661
rs1860661
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0220597
Disease:
Adult Hodgkin Lymphoma
0.010 GeneticVariation BEFREE We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI) = 0.76-0.86, P(combined) = 3.5 × 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. 24920014 2014
dbSNP: rs1052918
rs1052918
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Finally, we determined that rs3106189, localized to the 5' UTR of antigen presenting tapasin binding protein (TAPBP), and rs1052918, localized to the 3' UTR of transcription factor 3 (TCF3), were associated with overall survival of CRC patients. 23940558 2013
dbSNP: rs368163858
rs368163858
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0014175
Disease:
Endometriosis
0.010 GeneticVariation BEFREE RESULTS There was no association between the BDNF Val66Met polymorphism and overall endometriosis (P> 0.05), whereas higher genotype and allele frequencies of the BDNF(Met) polymorphism were found in the Stage III-IV endometriosis (both P< 0.01) and endometriosis-related infertile patients (both P< 0.05). 22447624 2012
dbSNP: rs1378286181
rs1378286181
Entrez Id: 6929
Gene Symbol: TCF3
TCF3
CUI: C0595989
Disease:
Carcinoma of larynx
0.010 GeneticVariation BEFREE The TNFR55-selective mutants (R32W, E146K and R32W-S86T) which bind poorly to TNFR75 displayed similar potency to wild-type TNF in causing cytotoxicity of a human laryngeal carcinoma-derived cell line (HEp-2) and cytostasis in a human leukaemic cell line (U937). 7509279 1994