TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4986791
rs4986791
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0027627
Disease:
Neoplasm Metastasis
0.020 GeneticVariation BEFREE All polymorphisms detected were also significantly associated with the metastatic disease (p<0.001) leading to shorter overall survival (p<0.001); whereas, TLR4 Asp299Gly and Thr399Ile polymorphisms were significantly associated with KRAS mutations. 29883450 2018
dbSNP: rs4986791
rs4986791
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0027627
Disease:
Neoplasm Metastasis
0.020 GeneticVariation BEFREE Finally, we observed a positive link between D299G and T399I polymorphisms and CRC patients with lymph node (p = 0.00024; p = 0.0005, respectively) and metastasis (p = 0.001; p = 0.002, respectively). 23949880 2014